Enzyme-degradable self-assembled hydrogels from polyalanine-modified poly(ethylene glycol) star polymers

Paul D. Thornton, Shah M. Reduwan Billah, Neil R. Cameron

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

The generation of a range of star-shaped block copolymers composed of a biocompatible poly(ethylene glycol) (PEG) core tethered to a polyalanine (PAla) shell that possesses the capability to (reversibly) self-assemble in water is described. The hydrogels formed offer a hydrophilic environment ideal for biological processes involving proteins and are able to withhold albumin for prolonged periods before its triggered release following the targeted material degradation by the proteolytic enzyme elastase. Consequently, the materials formed offer significant promise for the delivery of proteins, and possibly inhibitors, in response to a proteolytic enzyme overexpressed in chronic wounds.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalMacromolecular Rapid Communications
Volume34
Issue number3
DOIs
Publication statusPublished - 12 Feb 2013
Externally publishedYes

Keywords

  • Biomaterials
  • Drug delivery systems
  • Hydrogels
  • Peptides
  • Self-assembly

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