Enzymatic Cascade to Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign

Julien Tailhades, Yongwei Zhao, Melanie Schoppet, Anja Greule, Robert J. A. Goode, Ralf B. Schittenhelm, James J. De Voss, Max J. Cryle

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Natural products are the greatest source of antimicrobial agents, although their structural complexity often renders synthetic production and diversification of key classes impractical. One pertinent example is the glycopeptide antibiotics (GPAs), which are highly challenging to synthesize due to their heavily cross-linked structures. Here, we report an optimized method that generates >75% tricyclic peptides from synthetic precursors in order to explore the acceptance of novel GPA precursor peptides by these key existent biosynthetic enzymes.

Original languageEnglish
Pages (from-to)8635-8640
Number of pages6
JournalOrganic Letters
Volume21
Issue number21
DOIs
Publication statusPublished - 1 Nov 2019

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