TY - JOUR
T1 - Enlightening the role of high mobility group box 1 (HMGB1) in inflammation
T2 - Updates on receptor signalling
AU - Paudel, Yam Nath
AU - Angelopoulou, Efthalia
AU - Piperi, Christina
AU - Balasubramaniam, Vinod R.M.T.
AU - Othman, Iekhsan
AU - Shaikh, Mohd Farooq
PY - 2019/9/5
Y1 - 2019/9/5
N2 - High mobility group box 1 (HMGB1) is a ubiquitous protein, released passively by necrotic tissues or secreted actively by stressed cells. Extracellular HMGB1 is a typical damage-associated molecular pattern (DAMP) molecule which generates different redox types through binding with several receptors and signalling molecules, aggravating a range of cellular responses, including inflammation. HMGB1 is reported to participate in the pathogenesis of inflammatory diseases, through the interaction with pivotal transmembrane receptors, including the receptor for advanced glycation end products (RAGE) and toll-like receptor-4 (TLR-4). This review aims to highlight the role of HMGB1 in the innate inflammatory response describing its interaction with several cofactors and receptors that coordinate its downstream effects. Novel and underexplored HMGB1 binding molecules that have been actively involved in HMGB1-mediated inflammatory diseases/conditions with therapeutic potential are further discussed.
AB - High mobility group box 1 (HMGB1) is a ubiquitous protein, released passively by necrotic tissues or secreted actively by stressed cells. Extracellular HMGB1 is a typical damage-associated molecular pattern (DAMP) molecule which generates different redox types through binding with several receptors and signalling molecules, aggravating a range of cellular responses, including inflammation. HMGB1 is reported to participate in the pathogenesis of inflammatory diseases, through the interaction with pivotal transmembrane receptors, including the receptor for advanced glycation end products (RAGE) and toll-like receptor-4 (TLR-4). This review aims to highlight the role of HMGB1 in the innate inflammatory response describing its interaction with several cofactors and receptors that coordinate its downstream effects. Novel and underexplored HMGB1 binding molecules that have been actively involved in HMGB1-mediated inflammatory diseases/conditions with therapeutic potential are further discussed.
KW - DAMP
KW - HMGB1
KW - Inflammation
KW - LPS
KW - Pro-inflammatory
KW - TLR4
UR - http://www.scopus.com/inward/record.url?scp=85067896907&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2019.172487
DO - 10.1016/j.ejphar.2019.172487
M3 - Review Article
C2 - 31229535
AN - SCOPUS:85067896907
VL - 858
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
M1 - 172487
ER -