Enhancing immune responses by targeting antigen to DC

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87 Citations (Scopus)

Abstract

mAb that recognise various cell surface receptors have been used to deliver antigen to DC and thereby elicit immune responses. The encouraging data obtained in mouse models suggests that this immunisation strategy is efficient and could lead to clinical trials. We discuss a number of issues pertinent to this vaccination approach. These include which molecules are the best targets for delivering antigen to DC, which DC subtypes should be targeted, the types of immune responses to be generated and whether additional adjuvants are required. Finally, we discuss some progress towards targeting antigen to human DC.

Original languageEnglish
Pages (from-to)931-938
Number of pages8
JournalEuropean Journal of Immunology
Volume39
Issue number4
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • C-type lectins
  • Clec9A
  • DC
  • Targeting
  • Vaccination

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