Enhancing dendritic cell activation and HIV vaccine effectiveness through nanoparticle vaccination

Joshua J. Glass, Stephen J. Kent, Robert De Rose

Research output: Contribution to journalReview ArticleResearchpeer-review

21 Citations (Scopus)

Abstract

ABSTRACT: Novel vaccination approaches are needed to prevent and control human immunodeficiency virus (HIV) infection. A growing body of literature demonstrates the potential of nanotechnology to modulate the human immune system and generate targeted, controlled immune responses. In this Review, we summarize important advances in how ‘nanovaccinology’ can be used to develop safe and effective vaccines for HIV. We highlight the central role of dendritic cells in the immune response to vaccination and describe how nanotechnology can be used to enhance delivery to and activation of these important antigen-presenting cells. Strategies employed to improve biodistribution are discussed, including improved lymph node delivery and mucosal penetration concepts, before detailing methods to enhance the humoral and/or cellular immune response to vaccines. We conclude with a commentary on the current state of nanovaccinology.

Original languageEnglish
Pages (from-to)719-729
Number of pages11
JournalExpert Review of Vaccines
Volume15
Issue number6
DOIs
Publication statusPublished - 2 Jun 2016

Keywords

  • adjuvant
  • dendritic cell
  • HIV
  • nanovaccinology
  • vaccine

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