Enhancing active surveillance of prostate cancer: The potential of exercise medicine

Daniel A. Galvao, Dennis R. Taaffe, Nigel Spry, Robert A. Gardiner, Renea Taylor, Gail P. Risbridger, Mark Frydenberg, Michelle Hill, Suzanne K. Chambers, Phillip Stricker, Tom Shannon, Dickon Hayne, Eva Zopf, Robert U. Newton

Research output: Contribution to journal › Review Article › Other › peer-review

12 Citations (Scopus)

Abstract

Active surveillance (AS) is a strategy for the management of patients with low-risk, localized prostate cancer, in which men undergo regular monitoring of serum PSA levels and tumour characteristics, using multiparametric MRI and repeat biopsy sampling, to identify signs of disease progression. This strategy reduces overtreatment of clinically insignificant disease while also preserving opportunities for curative therapy in patients whose disease progresses. Preliminary studies of lifestyle interventions involving basic exercise advice have indicated that exercise reduces the numbers of patients undergoing active treatment, as well as modulating the biological processes involved in tumour progression. Therefore, preliminary evidence suggests that lifestyle and/or exercise interventions might have therapeutic potential in this growing population of men with prostate cancer. However, several important issues remain unclear: the exact value of different types of lifestyle and exercise medicine interventions during AS; the biological mechanisms of exercise in delaying disease progression; and the influence of the anxieties and distress created by having a diagnosis of cancer without then receiving active treatment. Future studies are required to confirm and expand these findings and determine the relative contributions of each lifestyle component to specific end points and patient outcomes during AS.
Original languageEnglish
Pages (from-to)258-265
Number of pages8
JournalNature Reviews Urology
Volume13
Issue number5
DOIs
Publication statusPublished - May 2016

Keywords

  • adverse effects
  • disease-free survival
  • prostate cancer
  • quality of life

Cite this

Galvao, Daniel A. ; Taaffe, Dennis R. ; Spry, Nigel ; Gardiner, Robert A. ; Taylor, Renea ; Risbridger, Gail P. ; Frydenberg, Mark ; Hill, Michelle ; Chambers, Suzanne K. ; Stricker, Phillip ; Shannon, Tom ; Hayne, Dickon ; Zopf, Eva ; Newton, Robert U. / Enhancing active surveillance of prostate cancer : The potential of exercise medicine. In: Nature Reviews Urology. 2016 ; Vol. 13, No. 5. pp. 258-265.
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title = "Enhancing active surveillance of prostate cancer: The potential of exercise medicine",
abstract = "Active surveillance (AS) is a strategy for the management of patients with low-risk, localized prostate cancer, in which men undergo regular monitoring of serum PSA levels and tumour characteristics, using multiparametric MRI and repeat biopsy sampling, to identify signs of disease progression. This strategy reduces overtreatment of clinically insignificant disease while also preserving opportunities for curative therapy in patients whose disease progresses. Preliminary studies of lifestyle interventions involving basic exercise advice have indicated that exercise reduces the numbers of patients undergoing active treatment, as well as modulating the biological processes involved in tumour progression. Therefore, preliminary evidence suggests that lifestyle and/or exercise interventions might have therapeutic potential in this growing population of men with prostate cancer. However, several important issues remain unclear: the exact value of different types of lifestyle and exercise medicine interventions during AS; the biological mechanisms of exercise in delaying disease progression; and the influence of the anxieties and distress created by having a diagnosis of cancer without then receiving active treatment. Future studies are required to confirm and expand these findings and determine the relative contributions of each lifestyle component to specific end points and patient outcomes during AS.",
keywords = "adverse effects, disease-free survival, prostate cancer, quality of life",
author = "Galvao, {Daniel A.} and Taaffe, {Dennis R.} and Nigel Spry and Gardiner, {Robert A.} and Renea Taylor and Risbridger, {Gail P.} and Mark Frydenberg and Michelle Hill and Chambers, {Suzanne K.} and Phillip Stricker and Tom Shannon and Dickon Hayne and Eva Zopf and Newton, {Robert U.}",
year = "2016",
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Galvao, DA, Taaffe, DR, Spry, N, Gardiner, RA, Taylor, R, Risbridger, GP, Frydenberg, M, Hill, M, Chambers, SK, Stricker, P, Shannon, T, Hayne, D, Zopf, E & Newton, RU 2016, 'Enhancing active surveillance of prostate cancer: The potential of exercise medicine', Nature Reviews Urology, vol. 13, no. 5, pp. 258-265. https://doi.org/10.1038/nrurol.2016.46

Enhancing active surveillance of prostate cancer : The potential of exercise medicine. / Galvao, Daniel A.; Taaffe, Dennis R.; Spry, Nigel; Gardiner, Robert A.; Taylor, Renea; Risbridger, Gail P.; Frydenberg, Mark; Hill, Michelle; Chambers, Suzanne K.; Stricker, Phillip; Shannon, Tom; Hayne, Dickon; Zopf, Eva; Newton, Robert U.

In: Nature Reviews Urology, Vol. 13, No. 5, 05.2016, p. 258-265.

Research output: Contribution to journal › Review Article › Other › peer-review

TY - JOUR

T1 - Enhancing active surveillance of prostate cancer

T2 - The potential of exercise medicine

AU - Galvao, Daniel A.

AU - Taaffe, Dennis R.

AU - Spry, Nigel

AU - Gardiner, Robert A.

AU - Taylor, Renea

AU - Risbridger, Gail P.

AU - Frydenberg, Mark

AU - Hill, Michelle

AU - Chambers, Suzanne K.

AU - Stricker, Phillip

AU - Shannon, Tom

AU - Hayne, Dickon

AU - Zopf, Eva

AU - Newton, Robert U.

PY - 2016/5

Y1 - 2016/5

N2 - Active surveillance (AS) is a strategy for the management of patients with low-risk, localized prostate cancer, in which men undergo regular monitoring of serum PSA levels and tumour characteristics, using multiparametric MRI and repeat biopsy sampling, to identify signs of disease progression. This strategy reduces overtreatment of clinically insignificant disease while also preserving opportunities for curative therapy in patients whose disease progresses. Preliminary studies of lifestyle interventions involving basic exercise advice have indicated that exercise reduces the numbers of patients undergoing active treatment, as well as modulating the biological processes involved in tumour progression. Therefore, preliminary evidence suggests that lifestyle and/or exercise interventions might have therapeutic potential in this growing population of men with prostate cancer. However, several important issues remain unclear: the exact value of different types of lifestyle and exercise medicine interventions during AS; the biological mechanisms of exercise in delaying disease progression; and the influence of the anxieties and distress created by having a diagnosis of cancer without then receiving active treatment. Future studies are required to confirm and expand these findings and determine the relative contributions of each lifestyle component to specific end points and patient outcomes during AS.

AB - Active surveillance (AS) is a strategy for the management of patients with low-risk, localized prostate cancer, in which men undergo regular monitoring of serum PSA levels and tumour characteristics, using multiparametric MRI and repeat biopsy sampling, to identify signs of disease progression. This strategy reduces overtreatment of clinically insignificant disease while also preserving opportunities for curative therapy in patients whose disease progresses. Preliminary studies of lifestyle interventions involving basic exercise advice have indicated that exercise reduces the numbers of patients undergoing active treatment, as well as modulating the biological processes involved in tumour progression. Therefore, preliminary evidence suggests that lifestyle and/or exercise interventions might have therapeutic potential in this growing population of men with prostate cancer. However, several important issues remain unclear: the exact value of different types of lifestyle and exercise medicine interventions during AS; the biological mechanisms of exercise in delaying disease progression; and the influence of the anxieties and distress created by having a diagnosis of cancer without then receiving active treatment. Future studies are required to confirm and expand these findings and determine the relative contributions of each lifestyle component to specific end points and patient outcomes during AS.

KW - adverse effects

KW - disease-free survival

KW - prostate cancer

KW - quality of life

UR - http://www.ncbi.nlm.nih.gov/pubmed/26954333

U2 - 10.1038/nrurol.2016.46

DO - 10.1038/nrurol.2016.46

M3 - Review Article

VL - 13

SP - 258

EP - 265

JO - Nature Clinical Practice Urology

JF - Nature Clinical Practice Urology

SN - 1759-4812

IS - 5

ER -

Galvao DA, Taaffe DR, Spry N, Gardiner RA, Taylor R, Risbridger GP et al. Enhancing active surveillance of prostate cancer: The potential of exercise medicine. Nature Reviews Urology. 2016 May;13(5):258-265. https://doi.org/10.1038/nrurol.2016.46

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