Enhancement of working memory and task-related oscillatory activity following intermittent theta burst stimulation in healthy controls

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Noninvasive brain stimulation is increasingly being investigated for the enhancement of cognition, yet current approaches appear to be limited in their degree and duration of effects. The majority of studies to date have delivered stimulation in "standard" ways (i.e., anodal transcranial direct current stimulation or high-frequency transcranial magnetic stimulation). Specialized forms of stimulation, such as theta burst stimulation (TBS), which more closely mimic the brains natural firing patterns may have greater effects on cognitive performance. We report here the findings from the first-ever investigation into the persistent cognitive and electrophysiological effects of intermittent TBS (iTBS) delivered to the left dorsolateral prefrontal cortex. In 19 healthy controls, active iTBS significantly improved performance on an assessment of working memory when compared with sham stimulation across a period of 40 min post stimulation. The behavioral findings were accompanied by increases in task-related fronto-parietal theta sychronization and parietal gamma band power. These results have implications for the role of more specialized stimulation approaches in neuromodulation.

Original languageEnglish
Pages (from-to)4563-4573
Number of pages11
JournalCerebral Cortex
Volume26
Issue number12
DOIs
Publication statusPublished - 2016

Keywords

  • Cortical oscillations
  • Dorsolateral prefrontal cortex
  • Theta burst stimulation
  • Working memo

Cite this

@article{4d3b232ecdfd4b248232932001c32eae,
title = "Enhancement of working memory and task-related oscillatory activity following intermittent theta burst stimulation in healthy controls",
abstract = "Noninvasive brain stimulation is increasingly being investigated for the enhancement of cognition, yet current approaches appear to be limited in their degree and duration of effects. The majority of studies to date have delivered stimulation in {"}standard{"} ways (i.e., anodal transcranial direct current stimulation or high-frequency transcranial magnetic stimulation). Specialized forms of stimulation, such as theta burst stimulation (TBS), which more closely mimic the brains natural firing patterns may have greater effects on cognitive performance. We report here the findings from the first-ever investigation into the persistent cognitive and electrophysiological effects of intermittent TBS (iTBS) delivered to the left dorsolateral prefrontal cortex. In 19 healthy controls, active iTBS significantly improved performance on an assessment of working memory when compared with sham stimulation across a period of 40 min post stimulation. The behavioral findings were accompanied by increases in task-related fronto-parietal theta sychronization and parietal gamma band power. These results have implications for the role of more specialized stimulation approaches in neuromodulation.",
keywords = "Cortical oscillations, Dorsolateral prefrontal cortex, Theta burst stimulation, Working memo",
author = "Hoy, {Kate E.} and Neil Bailey and Marco Michael and Bernadette Fitzgibbon and Rogasch, {Nigel C.} and Takashi Saeki and Fitzgerald, {Paul B.}",
year = "2016",
doi = "10.1093/cercor/bhv193",
language = "English",
volume = "26",
pages = "4563--4573",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Enhancement of working memory and task-related oscillatory activity following intermittent theta burst stimulation in healthy controls

AU - Hoy, Kate E.

AU - Bailey, Neil

AU - Michael, Marco

AU - Fitzgibbon, Bernadette

AU - Rogasch, Nigel C.

AU - Saeki, Takashi

AU - Fitzgerald, Paul B.

PY - 2016

Y1 - 2016

N2 - Noninvasive brain stimulation is increasingly being investigated for the enhancement of cognition, yet current approaches appear to be limited in their degree and duration of effects. The majority of studies to date have delivered stimulation in "standard" ways (i.e., anodal transcranial direct current stimulation or high-frequency transcranial magnetic stimulation). Specialized forms of stimulation, such as theta burst stimulation (TBS), which more closely mimic the brains natural firing patterns may have greater effects on cognitive performance. We report here the findings from the first-ever investigation into the persistent cognitive and electrophysiological effects of intermittent TBS (iTBS) delivered to the left dorsolateral prefrontal cortex. In 19 healthy controls, active iTBS significantly improved performance on an assessment of working memory when compared with sham stimulation across a period of 40 min post stimulation. The behavioral findings were accompanied by increases in task-related fronto-parietal theta sychronization and parietal gamma band power. These results have implications for the role of more specialized stimulation approaches in neuromodulation.

AB - Noninvasive brain stimulation is increasingly being investigated for the enhancement of cognition, yet current approaches appear to be limited in their degree and duration of effects. The majority of studies to date have delivered stimulation in "standard" ways (i.e., anodal transcranial direct current stimulation or high-frequency transcranial magnetic stimulation). Specialized forms of stimulation, such as theta burst stimulation (TBS), which more closely mimic the brains natural firing patterns may have greater effects on cognitive performance. We report here the findings from the first-ever investigation into the persistent cognitive and electrophysiological effects of intermittent TBS (iTBS) delivered to the left dorsolateral prefrontal cortex. In 19 healthy controls, active iTBS significantly improved performance on an assessment of working memory when compared with sham stimulation across a period of 40 min post stimulation. The behavioral findings were accompanied by increases in task-related fronto-parietal theta sychronization and parietal gamma band power. These results have implications for the role of more specialized stimulation approaches in neuromodulation.

KW - Cortical oscillations

KW - Dorsolateral prefrontal cortex

KW - Theta burst stimulation

KW - Working memo

UR - http://www.scopus.com/inward/record.url?scp=85014935330&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhv193

DO - 10.1093/cercor/bhv193

M3 - Article

VL - 26

SP - 4563

EP - 4573

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 12

ER -