Enhancement of interfacial catalysis in a triphase reactor using oxygen nanocarriers

Multiphase catalysis is used in many industrial processes; however, the reaction rate can be restricted by the low accessibility of gaseous reactants to the catalysts in water, especially for oxygen-dependent biocatalytic reactions. Despite the fact that solubility and diffusion rates of oxygen in many liquids (such as perfluorocarbon) are much higher than in water, multiphase reactions with a second liquid phase are still difficult to conduct, because the interaction efficiency between immiscible phases is extremely low. Herein, we report an efficient triphase biocatalytic system using oil core–silica shell oxygen nanocarriers. Such design offers the biocatalytic system an extremely large water-solid-oil triphase interfacial area and a short path required for oxygen diffusion. Moreover, the silica shell stabilizes the oil nanodroplets in water and prevents their aggregation. Using oxygen-dependent oxidase enzymatic reaction as an example, we demonstrate this efficient biocatalytic system for the oxidation of glucose, choline, lactate, and sucrose by substituting their corresponding oxidase counterparts. A rate enhancement by a factor of 10–30 is observed when the oxygen nanocarriers are introduced into reaction system. This strategy offers the opportunity to enhance the efficiency of other gaseous reactants involved in multiphase catalytic reactions. [Figure not available: see fulltext.].