Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Secondo Sonza; Adam Johnson; David Tyssen; Tim Denis Spelman; Gareth R Lewis; Jeremy R A Paull; Gilda Tachedjian

doi:10.1128/AAC.00102-09

Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Secondo Sonza, Adam Johnson, David Tyssen, Tim Denis Spelman, Gareth R Lewis, Jeremy R A Paull, Gilda Tachedjian

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Polyanion-based microbicides have been developed to prevent the sexual transmission of HIV. Recent data suggest that polyanions have the capacity to enhance HIV-1 replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon(R)). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.

Original language	English
Pages (from-to)	3565 - 3568
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	53
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00102-09
Publication status	Published - 2009

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10.1128/AAC.00102-09

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abstract = "Polyanion-based microbicides have been developed to prevent the sexual transmission of HIV. Recent data suggest that polyanions have the capacity to enhance HIV-1 replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon(R)). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.",

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AU - Sonza, Secondo

AU - Johnson, Adam

AU - Tyssen, David

AU - Spelman, Tim Denis

AU - Lewis, Gareth R

AU - Paull, Jeremy R A

AU - Tachedjian, Gilda

PY - 2009

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AB - Polyanion-based microbicides have been developed to prevent the sexual transmission of HIV. Recent data suggest that polyanions have the capacity to enhance HIV-1 replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon(R)). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.

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UR - https://www.scopus.com/pages/publications/67749110106

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Abstract

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