Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Secondo Sonza, Adam Johnson, David Tyssen, Tim Denis Spelman, Gareth R Lewis, Jeremy R A Paull, Gilda Tachedjian

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Polyanion-based microbicides have been developed to prevent the sexual transmission of HIV. Recent data suggest that polyanions have the capacity to enhance HIV-1 replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon(R)). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
Original languageEnglish
Pages (from-to)3565 - 3568
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number8
DOIs
Publication statusPublished - 2009

Cite this

Sonza, Secondo ; Johnson, Adam ; Tyssen, David ; Spelman, Tim Denis ; Lewis, Gareth R ; Paull, Jeremy R A ; Tachedjian, Gilda. / Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides. In: Antimicrobial Agents and Chemotherapy. 2009 ; Vol. 53, No. 8. pp. 3565 - 3568.
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Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides. / Sonza, Secondo; Johnson, Adam; Tyssen, David; Spelman, Tim Denis; Lewis, Gareth R; Paull, Jeremy R A; Tachedjian, Gilda.

In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 8, 2009, p. 3565 - 3568.

Research output: Contribution to journalArticleResearchpeer-review

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