Abstract
Polyanion-based microbicides have been developed to prevent the sexual transmission of HIV. Recent data suggest that polyanions have the capacity to enhance HIV-1 replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon(R)). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
Original language | English |
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Pages (from-to) | 3565 - 3568 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 53 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2009 |