Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides

Secondo Sonza, Adam Johnson, David Tyssen, Tim Denis Spelman, Gareth R Lewis, Jeremy R A Paull, Gilda Tachedjian

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Polyanion-based microbicides have been developed to prevent the sexual transmission of HIV. Recent data suggest that polyanions have the capacity to enhance HIV-1 replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon(R)). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
Original languageEnglish
Pages (from-to)3565 - 3568
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number8
Publication statusPublished - 2009

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