Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots

Sudaraka Mallawaarachchi; Malin Premaratne

doi:10.1109/NANOMED.2018.8641670

Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots

Sudaraka Mallawaarachchi, Malin Premaratne

Electrical and Computer Systems Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research

Abstract

Traditional cancer treatment modalities cause debilitating side-effects due to the harming of healthy tissues. With the advent of nanomedicine, nanoparticles have been used to target cancer cells while sparing healthy tissues. Using nanoparticles to induce hyperthermia by increasing tumor temperature is a potential first-line treatment modality with negligible side-effects. However, conventional nanoparticle sources lack precise controllability, causing the generated thermal photons to intractably penetrate the tumor boundary. This increases the temperature of adjacent healthy tissues, resulting in cytotoxic protein denaturation. Here, we investigate the suitability of a thermal superradiant pulse to enhance cancer hyperthermia. Our results indicate that the high intensity and ephemeral nature of the generated pulse using a circular quantum dot assembly can successfully alleviate this problem and enhance cancer hyperthermia.

Original language	English
Title of host publication	2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018)
Editors	Shih-Kang Fan
Place of Publication	Piscataway NJ USA
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	15-19
Number of pages	5
ISBN (Electronic)	9781538675786, 9781538675793
ISBN (Print)	9781538675809
DOIs	https://doi.org/10.1109/NANOMED.2018.8641670
Publication status	Published - 2018
Event	IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED) 2018 - Waikiki Beach, United States of America Duration: 2 Dec 2018 → 5 Dec 2018 Conference number: 12th

Publication series

Name	IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
Publisher	IEEE, Institute of Electrical and Electronics Engineers
ISSN (Print)	2159-6964
ISSN (Electronic)	2159-6972

Conference

Conference	IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED) 2018
Abbreviated title	NANOMED 2018
Country/Territory	United States of America
City	Waikiki Beach
Period	2/12/18 → 5/12/18

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/NANOMED.2018.8641670

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Mallawaarachchi, S., & Premaratne, M. (2018). Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. In S.-K. Fan (Ed.), 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018) (pp. 15-19). (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/NANOMED.2018.8641670

Mallawaarachchi, Sudaraka ; Premaratne, Malin. / Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). editor / Shih-Kang Fan. Piscataway NJ USA : IEEE, Institute of Electrical and Electronics Engineers, 2018. pp. 15-19 (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED).

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title = "Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots",

abstract = "Traditional cancer treatment modalities cause debilitating side-effects due to the harming of healthy tissues. With the advent of nanomedicine, nanoparticles have been used to target cancer cells while sparing healthy tissues. Using nanoparticles to induce hyperthermia by increasing tumor temperature is a potential first-line treatment modality with negligible side-effects. However, conventional nanoparticle sources lack precise controllability, causing the generated thermal photons to intractably penetrate the tumor boundary. This increases the temperature of adjacent healthy tissues, resulting in cytotoxic protein denaturation. Here, we investigate the suitability of a thermal superradiant pulse to enhance cancer hyperthermia. Our results indicate that the high intensity and ephemeral nature of the generated pulse using a circular quantum dot assembly can successfully alleviate this problem and enhance cancer hyperthermia.",

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year = "2018",

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booktitle = "2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018)",

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Mallawaarachchi, S & Premaratne, M 2018, Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. in S-K Fan (ed.), 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED, IEEE, Institute of Electrical and Electronics Engineers, Piscataway NJ USA, pp. 15-19, IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED) 2018, Waikiki Beach, Hawaii, United States of America, 2/12/18. https://doi.org/10.1109/NANOMED.2018.8641670

Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. / Mallawaarachchi, Sudaraka; Premaratne, Malin.
2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). ed. / Shih-Kang Fan. Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers, 2018. p. 15-19 (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research

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T1 - Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots

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AU - Premaratne, Malin

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N2 - Traditional cancer treatment modalities cause debilitating side-effects due to the harming of healthy tissues. With the advent of nanomedicine, nanoparticles have been used to target cancer cells while sparing healthy tissues. Using nanoparticles to induce hyperthermia by increasing tumor temperature is a potential first-line treatment modality with negligible side-effects. However, conventional nanoparticle sources lack precise controllability, causing the generated thermal photons to intractably penetrate the tumor boundary. This increases the temperature of adjacent healthy tissues, resulting in cytotoxic protein denaturation. Here, we investigate the suitability of a thermal superradiant pulse to enhance cancer hyperthermia. Our results indicate that the high intensity and ephemeral nature of the generated pulse using a circular quantum dot assembly can successfully alleviate this problem and enhance cancer hyperthermia.

AB - Traditional cancer treatment modalities cause debilitating side-effects due to the harming of healthy tissues. With the advent of nanomedicine, nanoparticles have been used to target cancer cells while sparing healthy tissues. Using nanoparticles to induce hyperthermia by increasing tumor temperature is a potential first-line treatment modality with negligible side-effects. However, conventional nanoparticle sources lack precise controllability, causing the generated thermal photons to intractably penetrate the tumor boundary. This increases the temperature of adjacent healthy tissues, resulting in cytotoxic protein denaturation. Here, we investigate the suitability of a thermal superradiant pulse to enhance cancer hyperthermia. Our results indicate that the high intensity and ephemeral nature of the generated pulse using a circular quantum dot assembly can successfully alleviate this problem and enhance cancer hyperthermia.

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Mallawaarachchi S, Premaratne M. Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. In Fan SK, editor, 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers. 2018. p. 15-19. (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED). doi: 10.1109/NANOMED.2018.8641670

Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots

Abstract

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