Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots

Sudaraka Mallawaarachchi, Malin Premaratne

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

Abstract

Traditional cancer treatment modalities cause debilitating side-effects due to the harming of healthy tissues. With the advent of nanomedicine, nanoparticles have been used to target cancer cells while sparing healthy tissues. Using nanoparticles to induce hyperthermia by increasing tumor temperature is a potential first-line treatment modality with negligible side-effects. However, conventional nanoparticle sources lack precise controllability, causing the generated thermal photons to intractably penetrate the tumor boundary. This increases the temperature of adjacent healthy tissues, resulting in cytotoxic protein denaturation. Here, we investigate the suitability of a thermal superradiant pulse to enhance cancer hyperthermia. Our results indicate that the high intensity and ephemeral nature of the generated pulse using a circular quantum dot assembly can successfully alleviate this problem and enhance cancer hyperthermia.

Original languageEnglish
Title of host publication2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018)
EditorsShih-Kang Fan
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages15-19
Number of pages5
ISBN (Electronic)9781538675786, 9781538675793
ISBN (Print)9781538675809
DOIs
Publication statusPublished - 2018
EventIEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED) 2018 - Waikiki Beach, United States of America
Duration: 2 Dec 20185 Dec 2018
Conference number: 12th

Publication series

NameIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
PublisherIEEE, Institute of Electrical and Electronics Engineers
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Conference

ConferenceIEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED) 2018
Abbreviated titleNANOMED 2018
CountryUnited States of America
CityWaikiki Beach
Period2/12/185/12/18

Cite this

Mallawaarachchi, S., & Premaratne, M. (2018). Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. In S-K. Fan (Ed.), 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018) (pp. 15-19). (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED). Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/NANOMED.2018.8641670
Mallawaarachchi, Sudaraka ; Premaratne, Malin. / Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). editor / Shih-Kang Fan. Piscataway NJ USA : IEEE, Institute of Electrical and Electronics Engineers, 2018. pp. 15-19 (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED).
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title = "Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots",
abstract = "Traditional cancer treatment modalities cause debilitating side-effects due to the harming of healthy tissues. With the advent of nanomedicine, nanoparticles have been used to target cancer cells while sparing healthy tissues. Using nanoparticles to induce hyperthermia by increasing tumor temperature is a potential first-line treatment modality with negligible side-effects. However, conventional nanoparticle sources lack precise controllability, causing the generated thermal photons to intractably penetrate the tumor boundary. This increases the temperature of adjacent healthy tissues, resulting in cytotoxic protein denaturation. Here, we investigate the suitability of a thermal superradiant pulse to enhance cancer hyperthermia. Our results indicate that the high intensity and ephemeral nature of the generated pulse using a circular quantum dot assembly can successfully alleviate this problem and enhance cancer hyperthermia.",
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Mallawaarachchi, S & Premaratne, M 2018, Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. in S-K Fan (ed.), 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED, IEEE, Institute of Electrical and Electronics Engineers, Piscataway NJ USA, pp. 15-19, IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED) 2018, Waikiki Beach, United States of America, 2/12/18. https://doi.org/10.1109/NANOMED.2018.8641670

Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. / Mallawaarachchi, Sudaraka; Premaratne, Malin.

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). ed. / Shih-Kang Fan. Piscataway NJ USA : IEEE, Institute of Electrical and Electronics Engineers, 2018. p. 15-19 (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

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AB - Traditional cancer treatment modalities cause debilitating side-effects due to the harming of healthy tissues. With the advent of nanomedicine, nanoparticles have been used to target cancer cells while sparing healthy tissues. Using nanoparticles to induce hyperthermia by increasing tumor temperature is a potential first-line treatment modality with negligible side-effects. However, conventional nanoparticle sources lack precise controllability, causing the generated thermal photons to intractably penetrate the tumor boundary. This increases the temperature of adjacent healthy tissues, resulting in cytotoxic protein denaturation. Here, we investigate the suitability of a thermal superradiant pulse to enhance cancer hyperthermia. Our results indicate that the high intensity and ephemeral nature of the generated pulse using a circular quantum dot assembly can successfully alleviate this problem and enhance cancer hyperthermia.

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Mallawaarachchi S, Premaratne M. Enhanced superradiant cancer hyperthermia using a ring shaped assembly of quantum dots. In Fan S-K, editor, 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2018). Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers. 2018. p. 15-19. (IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED). https://doi.org/10.1109/NANOMED.2018.8641670