Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade

Danika M Khong, Jarrod A Dudakov, Maree V Hammett, Marc I Jurblum, Sacha M L Khong, Gabrielle L Goldberg, Tomoo Ueno, Lisa G Spyroglou, Lauren Florence Young, Marcel R M van den Brink, Richard L Boyd, Ann P Chidgey

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13 Citations (Scopus)

Abstract

Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced lymphoid rejuvenation and enhanced recovery from hematopoietic stem cell (HSC) transplantation (HSCT). We herein show that, mechanistically, SSA induces hematopoietic and lymphoid recovery by functionally enhancing both HSC self-renewal and propensity for lymphoid differentiation through intrinsic molecular changes. Our transcriptome analysis revealed further hematopoietic support through rejuvenation of the bone marrow (BM) microenvironment, with upregulation of key hematopoietic factors and master regulatory factors associated with aging such as Foxo1. These studies provide important cellular and molecular insights into understanding how SSA-induced regeneration of the hematopoietic compartment can underpin recovery of the immune system following damaging cytoablative treatments. These findings support a short-term strategy for clinical use of SSA to enhance the production of lymphoid cells and HSC engraftment, leading to improved outcomes in adult patients undergoing HSCT and immune depletion in general.
Original languageEnglish
Pages (from-to)445 - 458
Number of pages14
JournalStem Cell Reports
Volume4
Issue number3
DOIs
Publication statusPublished - 2015

Cite this

Khong, D. M., Dudakov, J. A., Hammett, M. V., Jurblum, M. I., Khong, S. M. L., Goldberg, G. L., ... Chidgey, A. P. (2015). Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade. Stem Cell Reports, 4(3), 445 - 458. https://doi.org/10.1016/j.stemcr.2015.01.018