Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478

Fook-Thean Lee; Angela J Mountain; Marcus P Kelly; Cathrine Hall; Angela Rigopoulos; Terrance Grant Johns; Fiona E Smyth; Martin W Brechbiel; Edouard C Nice; Antony W Burgess; Andrew M Scott

doi:10.1158/1078-0432.CCR-1004-0019

Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478

Fook-Thean Lee
, Angela J Mountain
, Marcus P Kelly
, Cathrine Hall
, Angela Rigopoulos
, Terrance Grant Johns
, Fiona E Smyth
, Martin W Brechbiel
, Edouard C Nice
, Antony W Burgess
, Andrew M Scott

Research output: Contribution to journal › Article › Research › peer-review

85 Citations (Scopus)

Abstract

Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal growth factor receptor (EGFR) have been shown to enhance the effect of external beam radiation on EGFR-positive tumors. The effect of EGFR signaling abrogation by EGFR tyrosine kinase inhibitor on the efficacy of radioimmunotherapy has not been reported previously. This study investigated the effect of EGFR tyrosine kinase inhibition on the efficacy of radioimmunotherapy in a human cancer xenograft model.

Original language	English
Pages (from-to)	s7080 - s7086
Number of pages	7
Journal	Clinical Cancer Research
Volume	11
Issue number	19 (Pt 2)
DOIs	https://doi.org/10.1158/1078-0432.CCR-1004-0019
Publication status	Published - 2005
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1158/1078-0432.CCR-1004-0019

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Lee, F.-T., Mountain, A. J., Kelly, M. P., Hall, C., Rigopoulos, A., Johns, T. G., Smyth, F. E., Brechbiel, M. W., Nice, E. C., Burgess, A. W., & Scott, A. M. (2005). Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478. Clinical Cancer Research, 11(19 (Pt 2)), s7080 - s7086. https://doi.org/10.1158/1078-0432.CCR-1004-0019

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title = "Enhanced efficacy of radioimmunotherapy with90Y-CHX-A{"}- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478",

abstract = "Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal growth factor receptor (EGFR) have been shown to enhance the effect of external beam radiation on EGFR-positive tumors. The effect of EGFR signaling abrogation by EGFR tyrosine kinase inhibitor on the efficacy of radioimmunotherapy has not been reported previously. This study investigated the effect of EGFR tyrosine kinase inhibition on the efficacy of radioimmunotherapy in a human cancer xenograft model.",

author = "Fook-Thean Lee and Mountain, \{Angela J\} and Kelly, \{Marcus P\} and Cathrine Hall and Angela Rigopoulos and Johns, \{Terrance Grant\} and Smyth, \{Fiona E\} and Brechbiel, \{Martin W\} and Nice, \{Edouard C\} and Burgess, \{Antony W\} and Scott, \{Andrew M\}",

year = "2005",

doi = "10.1158/1078-0432.CCR-1004-0019",

language = "English",

volume = "11",

pages = "s7080 -- s7086",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research (AACR)",

number = "19 (Pt 2)",

}

Lee, F-T, Mountain, AJ, Kelly, MP, Hall, C, Rigopoulos, A, Johns, TG, Smyth, FE, Brechbiel, MW, Nice, EC, Burgess, AW & Scott, AM 2005, 'Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478', Clinical Cancer Research, vol. 11, no. 19 (Pt 2), pp. s7080 - s7086. https://doi.org/10.1158/1078-0432.CCR-1004-0019

Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478. / Lee, Fook-Thean; Mountain, Angela J; Kelly, Marcus P et al.
In: Clinical Cancer Research, Vol. 11, No. 19 (Pt 2), 2005, p. s7080 - s7086.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478

AU - Lee, Fook-Thean

AU - Mountain, Angela J

AU - Kelly, Marcus P

AU - Hall, Cathrine

AU - Rigopoulos, Angela

AU - Johns, Terrance Grant

AU - Smyth, Fiona E

AU - Brechbiel, Martin W

AU - Nice, Edouard C

AU - Burgess, Antony W

AU - Scott, Andrew M

PY - 2005

Y1 - 2005

N2 - Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal growth factor receptor (EGFR) have been shown to enhance the effect of external beam radiation on EGFR-positive tumors. The effect of EGFR signaling abrogation by EGFR tyrosine kinase inhibitor on the efficacy of radioimmunotherapy has not been reported previously. This study investigated the effect of EGFR tyrosine kinase inhibition on the efficacy of radioimmunotherapy in a human cancer xenograft model.

AB - Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal growth factor receptor (EGFR) have been shown to enhance the effect of external beam radiation on EGFR-positive tumors. The effect of EGFR signaling abrogation by EGFR tyrosine kinase inhibitor on the efficacy of radioimmunotherapy has not been reported previously. This study investigated the effect of EGFR tyrosine kinase inhibition on the efficacy of radioimmunotherapy in a human cancer xenograft model.

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U2 - 10.1158/1078-0432.CCR-1004-0019

DO - 10.1158/1078-0432.CCR-1004-0019

M3 - Article

SN - 1078-0432

VL - 11

SP - s7080 - s7086

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 19 (Pt 2)

ER -

Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478

Abstract

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