Enhanced efficacy of radioimmunotherapy with90Y-CHX-A"- DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478

Fook-Thean Lee, Angela J Mountain, Marcus P Kelly, Cathrine Hall, Angela Rigopoulos, Terrance Grant Johns, Fiona E Smyth, Martin W Brechbiel, Edouard C Nice, Antony W Burgess, Andrew M Scott

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51 Citations (Scopus)

Abstract

Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal growth factor receptor (EGFR) have been shown to enhance the effect of external beam radiation on EGFR-positive tumors. The effect of EGFR signaling abrogation by EGFR tyrosine kinase inhibitor on the efficacy of radioimmunotherapy has not been reported previously. This study investigated the effect of EGFR tyrosine kinase inhibition on the efficacy of radioimmunotherapy in a human cancer xenograft model.
Original languageEnglish
Pages (from-to)s7080 - s7086
Number of pages7
JournalClinical Cancer Research
Volume11
Issue number19 (Pt 2)
DOIs
Publication statusPublished - 2005
Externally publishedYes

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