Engineering vertically aligned semiconductor nanowire arrays for applications in the life sciences

Roey Elnathan, Moria Kwiat, Fernando Patolsky, Nicolas Hans Voelcker

Research output: Contribution to journalReview ArticleResearchpeer-review

108 Citations (Scopus)


The interface between nanotechnology and life sciences is one of the fastest-growing and most promising areas of material science. This review is following a recent shift toward the engineering of vertically aligned (VA) semiconductor nanowire (NW) arrays for the development of next-generation biodevices. The focus of the review is on porous and non-porous silicon and other semiconductor NWs. We will first cover key aspects of VA-NW array fabrication and chemical functionalization. Then we will concentrate on the interactions between VA-NW elements and mammalian cells. Specifically, we assess the ability of these nanostructures to influence cellular adhesion, morphology, migration, proliferation, and differentiation. We then address the use of vertically aligned NWs as tools for the delivery of biomolecular cargo into mammalian cells. The final sections of the review will be dedicated to examples of vertically aligned silicon nanowire (VA-SiNW) arrays used in drug delivery and for biosensing.
Original languageEnglish
Pages (from-to)172-196
Number of pages25
JournalNano Today
Issue number2
Publication statusPublished - 1 Apr 2014
Externally publishedYes


  • Bionanotechnology
  • Biosensing
  • Drug delivery
  • Gene delivery
  • Mammalian cells
  • Nanomaterials
  • Surface engineering
  • Vertically aligned nanowires

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