Engineering particles for therapeutic delivery: Prospects and challenges

Yan Yan, Georgina Kate Such, Angus Johnston, James P Best, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Abstract

Nanoengineered particles that can facilitate drug formulation and passively target tumors have reached the clinic in recent years. These early successes have driven a new wave of significant innovation in the generation of advanced particles. Recent developments in enabling technologies and chemistries have led to control over key particle properties, including surface functionality, size, shape, and rigidity. Combining these advances with the rapid developments in the discovery of many disease-related characteristics now offers new opportunities for improving particle specificity for targeted therapy. In this Perspective, we summarize recent progress in particle-based therapeutic delivery and discuss important concepts in particle design and biological barriers for developing the next generation of particles.
Original languageEnglish
Pages (from-to)3663 - 3669
Number of pages7
JournalACS Nano
Volume6
Issue number5
DOIs
Publication statusPublished - 2012
Externally publishedYes

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