Engineering multifunctional capsules through the assembly of metal-phenolic networks

Junling Guo, Hirotaka Ejima, Karen Maria Alt, Mirko V Meissner, Joseph J Richardson, Yan Yan, Karlheinz Peter, Dominik von Elverfeldt, Christoph Eugen Hagemeyer, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

787 Citations (Scopus)


Metal-organic coordination materials are of widespread interest because of the coupled benefits of inorganic and organic building blocks. These materials can be assembled into hollow capsules with a range of properties, which include selective permeability, enhanced mechanical/thermal stability, and stimuli-responsiveness. Previous studies have primarily focused on the assembly aspects of metal-coordination capsules; however, the engineering of metal-specific functionality for capsule design has not been explored. A library of functional metal-phenolic network (MPN) capsules prepared from a phenolic ligand (tannic acid) and a range of metals is reported. The properties of the MPN capsules are determined by the coordinated metals, allowing for control over film thickness, disassembly characteristics, and fluorescence behavior. Furthermore, the functional properties of the MPN capsules were tailored for drug delivery, positron emission tomography (PET), magnetic resonance imaging (MRI), and catalysis. The ability to incorporate multiple metals into MPN capsules demonstrates that a diverse range of functional materials can be generated. Multifunctional capsules: A common plant phenolic compound, tannic acid, can be used to coordinate a variety of metals through a one-step assembly process, thereby yielding a broad library of metal-phenolic network (MPN; see picture) capsules. The properties of the MPN capsules are determined by the coordinated metals.
Original languageEnglish
Pages (from-to)5546 - 5551
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number22
Publication statusPublished - 2014
Externally publishedYes

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