Engineering Escherichia coli to produce nonribosomal peptide antibiotics

Research output: Contribution to journalShort SurveyOtherpeer-review

6 Citations (Scopus)

Abstract

Genetic manipulation of biosynthetic pathways is a useful method for producing analogs of complex bioactive metabolites, but this technique can be challenging when performed in the natural producer of the target compounds. Reconstruction of biosynthetic gene clusters in E. coli could be the key to rapid heterologous production of natural products and genetic manipulation of their biosynthetic pathways.

Original languageEnglish
Pages (from-to)398-400
Number of pages3
JournalNature Chemical Biology
Volume2
Issue number8
DOIs
Publication statusPublished - 1 Jan 2006
Externally publishedYes

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