Engineering, characterization and directional self-assembly of anisotropically modified nanocolloids

Srijanani Bhaskar, Christopher T. Gibson, Mutsumi Yoshida, Himabindu Nandivada, Xiaopei Deng, Nicolas H. Voelcker, Joerg Lahann

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Along with traditional attributes such as the size, shape, and chemical structure of polymeric micro-objects, control over material distribution, or selective compartmentalization, appears to be increasingly important for maximizing the functionality and efficacy of biomaterials. The fabrication of tri- and tetracompartmental colloids made from biodegradable poly(lactide-co-glycolide) polymers via electrohydrodynamic co-jetting is demonstrated. The presence of three compartments is confirmed via flow cytometry. Additional chemical functionality is introduced via the incorporation of acetylene-functionalized polymers into individual compartments of the particles. Direct visualization of the spatioselective distribution of acetylene groups is demonstrated by confocal Raman microscopy as well as by reaction of the acetylene groups with azide-biotin via 'click chemistry'. Biotin-streptavidin binding is then utilized for the controlled assembly and orientation of bicompartmental particles onto functionalized, micropatterned substrates prepared via chemical vapor deposition polymerization.

Original languageEnglish
Pages (from-to)812-819
Number of pages8
JournalSmall
Volume7
Issue number6
DOIs
Publication statusPublished - 21 Mar 2011
Externally publishedYes

Keywords

  • anisotropy
  • biomaterials
  • biopolymers
  • self-assembly
  • surface modification

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