TY - JOUR
T1 - Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses
AU - Loessner, Daniela
AU - Holzapfel, Boris Michael
AU - Clements, Judith Ann
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Tissue engineering technologies, which have originally been designed to reconstitute damaged tissue structure and function, can mimic not only tissue regeneration processes but also cancer development and progression. Bioengineered approaches allow cell biologists to develop sophisticated experimentally and physiologically relevant cancer models to recapitulate the complexity of the disease seen in patients. Tissue engineering tools enable three-dimensionality based on the design of biomaterials and scaffolds that re-create the geometry, chemistry, function and signalling milieu of the native tumour microenvironment. Three-dimensional (3D) microenvironments, including cell-derived matrices, biomaterial-based cell culture models and integrated co-cultures with engineered stromal components, are powerful tools to study dynamic processes like proteolytic functions associated with cancer progression, metastasis and resistance to therapeutics. In this review, we discuss how biomimetic strategies can reproduce a humanised niche for human cancer cells, such as peritoneal or bone-like microenvironments, addressing specific aspects of ovarian and prostate cancer progression and therapy response.
AB - Tissue engineering technologies, which have originally been designed to reconstitute damaged tissue structure and function, can mimic not only tissue regeneration processes but also cancer development and progression. Bioengineered approaches allow cell biologists to develop sophisticated experimentally and physiologically relevant cancer models to recapitulate the complexity of the disease seen in patients. Tissue engineering tools enable three-dimensionality based on the design of biomaterials and scaffolds that re-create the geometry, chemistry, function and signalling milieu of the native tumour microenvironment. Three-dimensional (3D) microenvironments, including cell-derived matrices, biomaterial-based cell culture models and integrated co-cultures with engineered stromal components, are powerful tools to study dynamic processes like proteolytic functions associated with cancer progression, metastasis and resistance to therapeutics. In this review, we discuss how biomimetic strategies can reproduce a humanised niche for human cancer cells, such as peritoneal or bone-like microenvironments, addressing specific aspects of ovarian and prostate cancer progression and therapy response.
KW - 3D culture models
KW - Bone metastasis
KW - Humanised
KW - Intraperitoneal metastasis
KW - Preclinical drug testing
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84919660539&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2014.06.001
DO - 10.1016/j.addr.2014.06.001
M3 - Review Article
C2 - 24969478
AN - SCOPUS:84919660539
SN - 0169-409X
VL - 79-80
SP - 193
EP - 213
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -