Engineered hydrogen-bonded polymer multilayers: From assembly to biomedical applications

Georgina Kate Such, Angus Johnston, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

309 Citations (Scopus)

Abstract

Over the last two decades the layer-by-layer (LbL) assembly technique has become a highly versatile platform for the synthesis of nanoengineered thin films and particles. The widespread need for highly functional and responsive materials for applications in biomedicine - such as drug and gene delivery - has recently led to considerable efforts in the assembly of LbL materials, particularly films that can be subsequently stabilised and functionalised through a range of chemistries. In this tutorial review, recent developments in hydrogen-bonded LbL-assembled materials will be discussed, focusing on the design of materials with enhanced stimuli-responsive characteristics. Emphasis will be given to materials engineered for biomedical applications, specifically films/capsules that afford controlled loading and release of therapeutic cargo for application in vitro and in vivo.
Original languageEnglish
Pages (from-to)19 - 29
Number of pages11
JournalChemical Society Reviews
Volume40
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

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