Engineered bacterially expressed polypeptides: Assembly into polymer particles with tailored degradation profiles

Denison H C Chang; Angus P R Johnston; Kim L. Wark; Kerry Breheney; Frank Caruso

doi:10.1002/anie.201106033

Engineered bacterially expressed polypeptides: Assembly into polymer particles with tailored degradation profiles

Denison H C Chang, Angus P R Johnston, Kim L. Wark, Kerry Breheney, Frank Caruso

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

In nature, the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical functionality, and structure. It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles (see scheme).

Original language	English
Pages (from-to)	460-464
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	2
DOIs	https://doi.org/10.1002/anie.201106033
Publication status	Published - 9 Jan 2012
Externally published	Yes

Keywords

controlled degradation
drug delivery
peptides
polymer particles
positioned crosslinking

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10.1002/anie.201106033

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abstract = "In nature, the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical functionality, and structure. It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles (see scheme).",

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AU - Chang, Denison H C

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AU - Wark, Kim L.

AU - Breheney, Kerry

AU - Caruso, Frank

PY - 2012/1/9

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AB - In nature, the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical functionality, and structure. It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles (see scheme).

KW - controlled degradation

KW - drug delivery

KW - peptides

KW - polymer particles

KW - positioned crosslinking

UR - https://www.scopus.com/pages/publications/84855418024

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AN - SCOPUS:84855418024

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JF - Angewandte Chemie - International Edition

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Engineered bacterially expressed polypeptides: Assembly into polymer particles with tailored degradation profiles

Abstract

Keywords

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