Engineered bacterially expressed polypeptides: Assembly into polymer particles with tailored degradation profiles

Denison H C Chang, Angus P R Johnston, Kim L. Wark, Kerry Breheney, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

In nature, the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical functionality, and structure. It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles (see scheme).

Original languageEnglish
Pages (from-to)460-464
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number2
DOIs
Publication statusPublished - 9 Jan 2012
Externally publishedYes

Keywords

  • controlled degradation
  • drug delivery
  • peptides
  • polymer particles
  • positioned crosslinking

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