Engine-trailer-structured nanotrucks for efficient nano-bio interactions and bioimaging-guided drug delivery

Wenxing Wang, Peiyuan Wang, Liang Chen, Mengyao Zhao, Chin Te Hung, Chengzhong Yu, Areej Abdulkareem Al-Khalaf, Wael N. Hozzein, Fan Zhang, Xiaomin Li, Dongyuan Zhao

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)


We have rationally fabricated an asymmetric structured mesoporous nanotruck by the interfacial-energy-mediated anisotropic growth strategy. This nanotruck possesses distinguished dual domains: (1) spherical SiO2 head with a rough surface as an engine for enhanced nano-bio interactions and (2) a periodic mesoporous organosilica nanorod with high surface area as a trailer for efficient drug loading. The nanotrucks can be further functionalized by embedding functional nanoparticles in the rough heads and exhibit great potentials in biomedicine.

Original languageEnglish
Pages (from-to)1097-1112
Number of pages16
Issue number5
Publication statusPublished - 14 May 2020
Externally publishedYes


  • asymmetric nanomaterials
  • drug delivery
  • mesoporous silica
  • rough surfaces
  • SDG3: Good health and well-being

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