Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 413 - 421 |
| Number of pages | 9 |
| Journal | Hypertension Research |
| Volume | 37 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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Energy metabolism in BPH/2J genetically hypertensive mice. / Jackson, Kristy L; Nguyen-Huu, Thu-Phuc; Davern, Pamela J; Head, Geoffrey A.
In: Hypertension Research, Vol. 37, No. 5, 2014, p. 413 - 421.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Energy metabolism in BPH/2J genetically hypertensive mice
AU - Jackson, Kristy L
AU - Nguyen-Huu, Thu-Phuc
AU - Davern, Pamela J
AU - Head, Geoffrey A
PY - 2014
Y1 - 2014
N2 - Recent evidence indicates that genetic hypertension in BPH/2J mice is sympathetically mediated, but these mice also have lower body weight (BW) and elevated locomotor activity compared with BPN/3J normotensive mice, suggestive of metabolic abnormalities. The aim of the present study was to determine whether hypertension in BPH/2J mice is associated with metabolic differences. Whole-body metabolic and cardiovascular parameters were measured over 24 h by indirect calorimetry and radiotelemetry respectively, in conscious young (10-13 weeks) and older (22-23 weeks) BPH/2J, normotensive BPN/3J and C57Bl6 mice. Blood pressure (BP) was greater in BPH/2J compared with both normotensive strains at both ages (P0.1) suggesting differences in this relationship are not responsible for hypertension. EchoMRI revealed that percentage body composition was comparable in BPN/3J and BPH/2J mice (P>0.1) and both strains gained weight similarly with age (P=0.3). Taken together, the present findings indicate that hypertension in BPH/2J mice does not appear to be related to altered energy metabolism.
AB - Recent evidence indicates that genetic hypertension in BPH/2J mice is sympathetically mediated, but these mice also have lower body weight (BW) and elevated locomotor activity compared with BPN/3J normotensive mice, suggestive of metabolic abnormalities. The aim of the present study was to determine whether hypertension in BPH/2J mice is associated with metabolic differences. Whole-body metabolic and cardiovascular parameters were measured over 24 h by indirect calorimetry and radiotelemetry respectively, in conscious young (10-13 weeks) and older (22-23 weeks) BPH/2J, normotensive BPN/3J and C57Bl6 mice. Blood pressure (BP) was greater in BPH/2J compared with both normotensive strains at both ages (P0.1) suggesting differences in this relationship are not responsible for hypertension. EchoMRI revealed that percentage body composition was comparable in BPN/3J and BPH/2J mice (P>0.1) and both strains gained weight similarly with age (P=0.3). Taken together, the present findings indicate that hypertension in BPH/2J mice does not appear to be related to altered energy metabolism.
UR - http://www.nature.com/hr/journal/v37/n5/pdf/hr2013156a.pdf
U2 - 10.1038/hr.2013.156
DO - 10.1038/hr.2013.156
M3 - Article
VL - 37
SP - 413
EP - 421
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 5
ER -