Energy metabolism in BPH/2J genetically hypertensive mice

Kristy L Jackson, Thu-Phuc Nguyen-Huu, Pamela J Davern, Geoffrey A Head

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Recent evidence indicates that genetic hypertension in BPH/2J mice is sympathetically mediated, but these mice also have lower body weight (BW) and elevated locomotor activity compared with BPN/3J normotensive mice, suggestive of metabolic abnormalities. The aim of the present study was to determine whether hypertension in BPH/2J mice is associated with metabolic differences. Whole-body metabolic and cardiovascular parameters were measured over 24 h by indirect calorimetry and radiotelemetry respectively, in conscious young (10-13 weeks) and older (22-23 weeks) BPH/2J, normotensive BPN/3J and C57Bl6 mice. Blood pressure (BP) was greater in BPH/2J compared with both normotensive strains at both ages (P0.1) suggesting differences in this relationship are not responsible for hypertension. EchoMRI revealed that percentage body composition was comparable in BPN/3J and BPH/2J mice (P>0.1) and both strains gained weight similarly with age (P=0.3). Taken together, the present findings indicate that hypertension in BPH/2J mice does not appear to be related to altered energy metabolism.
Original languageEnglish
Pages (from-to)413 - 421
Number of pages9
JournalHypertension Research
Volume37
Issue number5
DOIs
Publication statusPublished - 2014

Cite this

Jackson, Kristy L ; Nguyen-Huu, Thu-Phuc ; Davern, Pamela J ; Head, Geoffrey A. / Energy metabolism in BPH/2J genetically hypertensive mice. In: Hypertension Research. 2014 ; Vol. 37, No. 5. pp. 413 - 421.
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abstract = "Recent evidence indicates that genetic hypertension in BPH/2J mice is sympathetically mediated, but these mice also have lower body weight (BW) and elevated locomotor activity compared with BPN/3J normotensive mice, suggestive of metabolic abnormalities. The aim of the present study was to determine whether hypertension in BPH/2J mice is associated with metabolic differences. Whole-body metabolic and cardiovascular parameters were measured over 24 h by indirect calorimetry and radiotelemetry respectively, in conscious young (10-13 weeks) and older (22-23 weeks) BPH/2J, normotensive BPN/3J and C57Bl6 mice. Blood pressure (BP) was greater in BPH/2J compared with both normotensive strains at both ages (P0.1) suggesting differences in this relationship are not responsible for hypertension. EchoMRI revealed that percentage body composition was comparable in BPN/3J and BPH/2J mice (P>0.1) and both strains gained weight similarly with age (P=0.3). Taken together, the present findings indicate that hypertension in BPH/2J mice does not appear to be related to altered energy metabolism.",
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Jackson, KL, Nguyen-Huu, T-P, Davern, PJ & Head, GA 2014, 'Energy metabolism in BPH/2J genetically hypertensive mice' Hypertension Research, vol. 37, no. 5, pp. 413 - 421. https://doi.org/10.1038/hr.2013.156

Energy metabolism in BPH/2J genetically hypertensive mice. / Jackson, Kristy L; Nguyen-Huu, Thu-Phuc; Davern, Pamela J; Head, Geoffrey A.

In: Hypertension Research, Vol. 37, No. 5, 2014, p. 413 - 421.

Research output: Contribution to journalArticleResearchpeer-review

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