Energy intake with respect to the development of diabetes mellitus in Psammomys obesus

M. Barnett, G. R. Collier, P. Zimmet, K. O'Dea

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Abstract

The aim of this study was to examine the relationship between hyperphagia, hyperglycemia and hyperinsulinemia in Psammomys obesus fed chow ad libitum. By 81 days, 3 separate groups of sand rats were apparent based on fed glucose and insulin levels; group 1 was normoglycemic (4.4 ± 0.3 mM) and normoinsulinemic (12 ± 1 mU/l), group 2 was normoglycemic (5.0 ± 0.3 mM) and hyperinsulinemic (93 ± 16 mU/l) and group 3 was hyperglycemic (11.2 ± 1.2 mM) and hyperinsulinemic (162 ± 19 mU/l). When compared with group 1, Psammomys obesus in group 3 developed the most abnormalities including increased levels of food intake (16.3 ± 0.5 vs 14.2 ± 0.5 g/day, p < 0.05), body weight (187 ± 7 vs 169.7 g, p < 0.05), triglycerides (1.5 ± 1.9 vs 0.96 ± 0.08 mM, p < 0.05), and cholesterol (3.7 ± 0.3 vs 3.2 ± 0.2 mM, p < 0.05). Epididymal, perirenal and subscapular fat stores were all significantly greater in group 3 when compared to group 2 (p < 0.05), and in group 2 when compared to group 1 (p < 0.05). The hyperinsulinemia present in group 2 and group 3 animals was associated with increased fat deposition. However, only group 3 developed hyperglycemia and was also the only group to demonstrate significantly greater levels of energy intake. These results have demonstrated an association between hyperinsulinemia and elevated fat deposition. In addition, only Psammomys obesus that were hyperphagic went on to develop hyperglycemia.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Volume8
Issue number1
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • Energy intake
  • Fat stores
  • Hyperglycemia
  • Hyperinsulinemia

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