Endotoxin-induced circulatory changes in the newborn brain: a review

Susan Y S Feng, Victor Y H Yu, Adrian Mark Walker

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Endotoxin induces complex changes in the newborn cerebral circulation, including vasoconstriction by down-regulating endothelial nitric oxide synthase and stimulating the production of endothelin and cyclooxygenase-2 derived vasoconstrictors including thromboxane A2, while also promoting vasodilatation by increasing the expression of inducible nitric oxide synthase and cyclooxygenase-2 derived vasodilators. Together, these changes represent a complex dysregulation of the newborn cerebral circulation. This review considers the effects of neonatal endotoxaemia on cerebral circulatory changes and endothelium-derived factors, and their implications for cerebral circulatory control.
Original languageEnglish
Pages (from-to)111 - 117
Number of pages7
JournalHong Kong Journal of Paediatrics
Volume12
Issue number2
Publication statusPublished - 2007

Cite this

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Endotoxin-induced circulatory changes in the newborn brain: a review. / Feng, Susan Y S; Yu, Victor Y H; Walker, Adrian Mark.

In: Hong Kong Journal of Paediatrics, Vol. 12, No. 2, 2007, p. 111 - 117.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Endotoxin induces complex changes in the newborn cerebral circulation, including vasoconstriction by down-regulating endothelial nitric oxide synthase and stimulating the production of endothelin and cyclooxygenase-2 derived vasoconstrictors including thromboxane A2, while also promoting vasodilatation by increasing the expression of inducible nitric oxide synthase and cyclooxygenase-2 derived vasodilators. Together, these changes represent a complex dysregulation of the newborn cerebral circulation. This review considers the effects of neonatal endotoxaemia on cerebral circulatory changes and endothelium-derived factors, and their implications for cerebral circulatory control.

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