Abstract
Endotoxin induces complex changes in the newborn cerebral circulation, including vasoconstriction by down-regulating endothelial nitric oxide synthase and stimulating the production of endothelin and cyclooxygenase-2 derived vasoconstrictors including thromboxane A2, while also promoting vasodilatation by increasing the expression of inducible nitric oxide synthase and cyclooxygenase-2 derived vasodilators. Together, these changes represent a complex dysregulation of the newborn cerebral circulation. This review considers the effects of neonatal endotoxaemia on cerebral circulatory changes and endothelium-derived factors, and their implications for cerebral circulatory control.
| Original language | English |
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| Pages (from-to) | 111 - 117 |
| Number of pages | 7 |
| Journal | Hong Kong Journal of Paediatrics |
| Volume | 12 |
| Issue number | 2 |
| Publication status | Published - 2007 |