TY - JOUR
T1 - Endothelium-dependent hyperpolarization
T2 - a role in the control of vascular tone
AU - Garland, Christopher J.
AU - Plane, Frances
AU - Kemp, Barbara K.
AU - Cocks, Thomas M.
PY - 1995
Y1 - 1995
N2 - Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of agonists, including cholinomimetics and substance P, is often accompanied by an increase (repolarization and/or hyperpolarization) in the membrane potential. This change in membrane potential appears predominately to reflect the action of an endothelial-derived hyperpolarizing factor (EDHF), which is distinct from NO (or endothelial-derived relaxing factor), and is discussed in this article by Chris Garland and colleagues. In large conducting arteries, EDHF may provide a secondary system to NO, which assumes primary importance in some disease states such as pulmonary hypertension and atherosclerosis. However, in small resistance arteries (100-300 μm), EDHF appears to be a major determinant of vascular calibre under normal conditions, and may therefore be of primary importance in the regulation of vascular resistance.
AB - Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of agonists, including cholinomimetics and substance P, is often accompanied by an increase (repolarization and/or hyperpolarization) in the membrane potential. This change in membrane potential appears predominately to reflect the action of an endothelial-derived hyperpolarizing factor (EDHF), which is distinct from NO (or endothelial-derived relaxing factor), and is discussed in this article by Chris Garland and colleagues. In large conducting arteries, EDHF may provide a secondary system to NO, which assumes primary importance in some disease states such as pulmonary hypertension and atherosclerosis. However, in small resistance arteries (100-300 μm), EDHF appears to be a major determinant of vascular calibre under normal conditions, and may therefore be of primary importance in the regulation of vascular resistance.
UR - http://www.scopus.com/inward/record.url?scp=0028835749&partnerID=8YFLogxK
U2 - 10.1016/S0165-6147(00)88969-5
DO - 10.1016/S0165-6147(00)88969-5
M3 - Review Article
C2 - 7732600
AN - SCOPUS:0028835749
SN - 0165-6147
VL - 16
SP - 23
EP - 30
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -