Endothelin converting Enzyme-1 phosphorylation and trafficking

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer s disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell. Production of ET-1 by ECE-1 occurs at the cell surface and the expression and localisation of ECE-1 is the rate limiting step in the production of ET-1. This review looks at the current knowledge on ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface.
Original languageEnglish
Pages (from-to)2212 - 2217
Number of pages6
JournalFEBS Letters
Volume586
Issue number16
DOIs
Publication statusPublished - 2012

Cite this

@article{e0175b5b97cb404eb54b5499195ac5df,
title = "Endothelin converting Enzyme-1 phosphorylation and trafficking",
abstract = "Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer s disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell. Production of ET-1 by ECE-1 occurs at the cell surface and the expression and localisation of ECE-1 is the rate limiting step in the production of ET-1. This review looks at the current knowledge on ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface.",
author = "Kuruppu, {D M Sanjaya} and Smith, {Alexander Ian}",
year = "2012",
doi = "10.1016/j.febslet.2012.06.020",
language = "English",
volume = "586",
pages = "2212 -- 2217",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Wiley-Blackwell",
number = "16",

}

Endothelin converting Enzyme-1 phosphorylation and trafficking. / Kuruppu, D M Sanjaya; Smith, Alexander Ian.

In: FEBS Letters, Vol. 586, No. 16, 2012, p. 2212 - 2217.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Endothelin converting Enzyme-1 phosphorylation and trafficking

AU - Kuruppu, D M Sanjaya

AU - Smith, Alexander Ian

PY - 2012

Y1 - 2012

N2 - Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer s disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell. Production of ET-1 by ECE-1 occurs at the cell surface and the expression and localisation of ECE-1 is the rate limiting step in the production of ET-1. This review looks at the current knowledge on ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface.

AB - Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer s disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell. Production of ET-1 by ECE-1 occurs at the cell surface and the expression and localisation of ECE-1 is the rate limiting step in the production of ET-1. This review looks at the current knowledge on ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface.

UR - http://www.sciencedirect.com/science/article/pii/S001457931200498X

U2 - 10.1016/j.febslet.2012.06.020

DO - 10.1016/j.febslet.2012.06.020

M3 - Article

VL - 586

SP - 2212

EP - 2217

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 16

ER -