Endothelin converting Enzyme-1 phosphorylation and trafficking

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Abstract

Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer s disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell. Production of ET-1 by ECE-1 occurs at the cell surface and the expression and localisation of ECE-1 is the rate limiting step in the production of ET-1. This review looks at the current knowledge on ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface.
Original languageEnglish
Pages (from-to)2212 - 2217
Number of pages6
JournalFEBS Letters
Volume586
Issue number16
DOIs
Publication statusPublished - 2012

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