Endothelial VEGF sculpts cortical cytoarchitecture

Suyan Li, Katharina Haigh, Jody Jonathan Haigh, Anju Vasudevan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Current models of brain development support the view that VEGF, a signaling protein secreted by neuronal cells, regulates angiogenesis and neuronal development. Here we demonstrate an autonomous and pivotal role for endothelial cell-derivedVEGFthat has far-reaching consequences for mouse brain development. Selective deletion of Vegf from endothelial cells resulted in impaired angiogenesis and marked perturbation of cortical cytoarchitecture. Abnormal cell clusters or heterotopias were detected in the marginal zone, and disorganization of cortical cells induced several malformations, including aberrant cortical lamination. Critical events during brain development-neuronal proliferation, differentiation, and migration were significantly affected. In addition, axonal tracts in the telencephalon were severely defective in the absence of endothelial VEGF. The unique roles of endothelial VEGF cannot be compensated by neuronal VEGF and underscores the high functional significance of endothelial VEGF for cerebral cortex development and from disease perspectives. ? 2013 the authors.
Original languageEnglish
Pages (from-to)14809 - 14815
Number of pages7
JournalJournal of Neuroscience
Volume33
Issue number37
DOIs
Publication statusPublished - 2013

Cite this

Li, S., Haigh, K., Haigh, J. J., & Vasudevan, A. (2013). Endothelial VEGF sculpts cortical cytoarchitecture. Journal of Neuroscience, 33(37), 14809 - 14815. https://doi.org/10.1523/JNEUROSCI.1368-13.2013
Li, Suyan ; Haigh, Katharina ; Haigh, Jody Jonathan ; Vasudevan, Anju. / Endothelial VEGF sculpts cortical cytoarchitecture. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 37. pp. 14809 - 14815.
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Li, S, Haigh, K, Haigh, JJ & Vasudevan, A 2013, 'Endothelial VEGF sculpts cortical cytoarchitecture' Journal of Neuroscience, vol. 33, no. 37, pp. 14809 - 14815. https://doi.org/10.1523/JNEUROSCI.1368-13.2013

Endothelial VEGF sculpts cortical cytoarchitecture. / Li, Suyan; Haigh, Katharina; Haigh, Jody Jonathan; Vasudevan, Anju.

In: Journal of Neuroscience, Vol. 33, No. 37, 2013, p. 14809 - 14815.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Vasudevan, Anju

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AB - Current models of brain development support the view that VEGF, a signaling protein secreted by neuronal cells, regulates angiogenesis and neuronal development. Here we demonstrate an autonomous and pivotal role for endothelial cell-derivedVEGFthat has far-reaching consequences for mouse brain development. Selective deletion of Vegf from endothelial cells resulted in impaired angiogenesis and marked perturbation of cortical cytoarchitecture. Abnormal cell clusters or heterotopias were detected in the marginal zone, and disorganization of cortical cells induced several malformations, including aberrant cortical lamination. Critical events during brain development-neuronal proliferation, differentiation, and migration were significantly affected. In addition, axonal tracts in the telencephalon were severely defective in the absence of endothelial VEGF. The unique roles of endothelial VEGF cannot be compensated by neuronal VEGF and underscores the high functional significance of endothelial VEGF for cerebral cortex development and from disease perspectives. ? 2013 the authors.

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