Projects per year
Abstract
Cellular therapy is an emerging field in clinical and personalised medicine. Many adult mesenchymal stem/progenitor cells (MSC) or pluripotent derivatives are being assessed simultaneously in preclinical trials for their potential treatment applications in chronic and degenerative human diseases. Endometrial mesenchymal stem/progenitor cells (eMSC) have been identified as clonogenic cells that exist in unique perivascular niches within the uterine endometrium. Compared with MSC isolated from other tissue sources, such as bone marrow and adipose tissue, eMSC can be extracted through less invasive methods of tissue sampling, and they exhibit improvements in potency, proliferative capacity, and control of culture-induced differentiation. In this review, we summarize the potential cell therapy and tissue engineering applications of eMSC in pelvic organ prolapse (POP), emphasising their ability to exert angiogenic and strong immunomodulatory responses that improve tissue integration of novel surgical constructs for POP and promote vaginal tissue healing.
Original language | English |
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Article number | 840 |
Number of pages | 21 |
Journal | Journal of Personalized Medicine |
Volume | 11 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2021 |
Keywords
- Biomaterials
- Bioscaffolds
- Cell culture
- Electrospinning
- Endometrium
- Menstrual blood
- MSC
- Nanofiber
- Perivascular MSC
- Tissue engineering
Projects
- 3 Finished
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Advancing Women’s Urogynecological Health using Micro/Nanotechnologies
Mukherjee, S., Werkmeister, J. A., Wood, B. & Rosamilia, A.
1/01/20 → 31/12/24
Project: Research
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Cells and nanobiomaterials to treat and prevent Pelvic Organ Prolapse
Gargett, C., Mukherjee, S., Brosens, J. J., Werkmeister, J. A., Rosamilia, A., Deane, J., Ott, S., Arkwright, J. W. & Weiss, A. S.
1/01/19 → 31/12/22
Project: Research