Endometrial SUSD2+ mesenchymal stem/stromal cells in tissue engineering: Advances in novel cellular constructs for pelvic organ prolapse

David M.Z.B. Hennes, Anna Rosamilia, Jerome A. Werkmeister, Caroline E. Gargett, Shayanti Mukherjee

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Cellular therapy is an emerging field in clinical and personalised medicine. Many adult mesenchymal stem/progenitor cells (MSC) or pluripotent derivatives are being assessed simultaneously in preclinical trials for their potential treatment applications in chronic and degenerative human diseases. Endometrial mesenchymal stem/progenitor cells (eMSC) have been identified as clonogenic cells that exist in unique perivascular niches within the uterine endometrium. Compared with MSC isolated from other tissue sources, such as bone marrow and adipose tissue, eMSC can be extracted through less invasive methods of tissue sampling, and they exhibit improvements in potency, proliferative capacity, and control of culture-induced differentiation. In this review, we summarize the potential cell therapy and tissue engineering applications of eMSC in pelvic organ prolapse (POP), emphasising their ability to exert angiogenic and strong immunomodulatory responses that improve tissue integration of novel surgical constructs for POP and promote vaginal tissue healing.

Original languageEnglish
Article number840
Number of pages21
JournalJournal of Personalized Medicine
Volume11
Issue number9
DOIs
Publication statusPublished - Sept 2021

Keywords

  • Biomaterials
  • Bioscaffolds
  • Cell culture
  • Electrospinning
  • Endometrium
  • Menstrual blood
  • MSC
  • Nanofiber
  • Perivascular MSC
  • Tissue engineering

Cite this