Endogenous endothelins and the response to electrical renal nerve stimulation in anaesthetized rabbits

Erika Ingrid Boesen, Warwick Peter Anderson, Roger George Evans, Michelle Monica Kett

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The influence of endogenous endothelins on the neural control of renal function is poorly understood. We therefore studied the effects of endothelin blockade (combined ETA and ETB receptor antagonism using TAK-044) on the acute and prolonged effects of renal nerve stimulation in rabbits, measuring renal blood flow, glomerular filtration rate (GFR), urine flow and sodium excretion. Brief (3 min) stimulation over 0.5-8 Hz produced frequency-dependent reductions in total renal blood flow, cortical blood flow and, less markedly, medullary blood flow. TAK-044 did not significantly alter basal total renal blood flow or cortical blood flow, or their responses to nerve stimulation, but significantly increased basal medullary blood flow (P <0.01) and increased the slope of the stimulation frequency-medullary blood flow relationship (P <0.05). Prolonged (20 min) stimulation at 0, M and 2 Hz produced frequency-dependent reductions in total renal blood flow, GFR, urine flow and sodium excretion, but not medullary blood flow. Pretreatment with TAK-044 did not significantly alter these responses. Thus, endogenous endothelins do not appear to either augment or lessen the effects of renal nerve activation on total renal blood flow, cortical blood flow, GFR or sodium excretion. The apparent ability of TAK-044 to enhance medullary blood flow responses to renal nerve stimulation may reflect an action of endogenous endothelins to blunt neurally mediated vasoconstriction in the medullary circulation. Alternatively, it may simply be secondary to the effects of endogenous endothelins on basal medullary blood flow. (c) 2006 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)8 - 15
Number of pages8
JournalAutonomic Neuroscience: Basic and Clinical
Volume132
Issue number1-2
Publication statusPublished - 2007

Cite this

@article{eb3b33fbbe2e4e7aa829daaf3ec2b94e,
title = "Endogenous endothelins and the response to electrical renal nerve stimulation in anaesthetized rabbits",
abstract = "The influence of endogenous endothelins on the neural control of renal function is poorly understood. We therefore studied the effects of endothelin blockade (combined ETA and ETB receptor antagonism using TAK-044) on the acute and prolonged effects of renal nerve stimulation in rabbits, measuring renal blood flow, glomerular filtration rate (GFR), urine flow and sodium excretion. Brief (3 min) stimulation over 0.5-8 Hz produced frequency-dependent reductions in total renal blood flow, cortical blood flow and, less markedly, medullary blood flow. TAK-044 did not significantly alter basal total renal blood flow or cortical blood flow, or their responses to nerve stimulation, but significantly increased basal medullary blood flow (P <0.01) and increased the slope of the stimulation frequency-medullary blood flow relationship (P <0.05). Prolonged (20 min) stimulation at 0, M and 2 Hz produced frequency-dependent reductions in total renal blood flow, GFR, urine flow and sodium excretion, but not medullary blood flow. Pretreatment with TAK-044 did not significantly alter these responses. Thus, endogenous endothelins do not appear to either augment or lessen the effects of renal nerve activation on total renal blood flow, cortical blood flow, GFR or sodium excretion. The apparent ability of TAK-044 to enhance medullary blood flow responses to renal nerve stimulation may reflect an action of endogenous endothelins to blunt neurally mediated vasoconstriction in the medullary circulation. Alternatively, it may simply be secondary to the effects of endogenous endothelins on basal medullary blood flow. (c) 2006 Elsevier B.V. All rights reserved.",
author = "Boesen, {Erika Ingrid} and Anderson, {Warwick Peter} and Evans, {Roger George} and Kett, {Michelle Monica}",
year = "2007",
language = "English",
volume = "132",
pages = "8 -- 15",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "1-2",

}

Endogenous endothelins and the response to electrical renal nerve stimulation in anaesthetized rabbits. / Boesen, Erika Ingrid; Anderson, Warwick Peter; Evans, Roger George; Kett, Michelle Monica.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 132, No. 1-2, 2007, p. 8 - 15.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Endogenous endothelins and the response to electrical renal nerve stimulation in anaesthetized rabbits

AU - Boesen, Erika Ingrid

AU - Anderson, Warwick Peter

AU - Evans, Roger George

AU - Kett, Michelle Monica

PY - 2007

Y1 - 2007

N2 - The influence of endogenous endothelins on the neural control of renal function is poorly understood. We therefore studied the effects of endothelin blockade (combined ETA and ETB receptor antagonism using TAK-044) on the acute and prolonged effects of renal nerve stimulation in rabbits, measuring renal blood flow, glomerular filtration rate (GFR), urine flow and sodium excretion. Brief (3 min) stimulation over 0.5-8 Hz produced frequency-dependent reductions in total renal blood flow, cortical blood flow and, less markedly, medullary blood flow. TAK-044 did not significantly alter basal total renal blood flow or cortical blood flow, or their responses to nerve stimulation, but significantly increased basal medullary blood flow (P <0.01) and increased the slope of the stimulation frequency-medullary blood flow relationship (P <0.05). Prolonged (20 min) stimulation at 0, M and 2 Hz produced frequency-dependent reductions in total renal blood flow, GFR, urine flow and sodium excretion, but not medullary blood flow. Pretreatment with TAK-044 did not significantly alter these responses. Thus, endogenous endothelins do not appear to either augment or lessen the effects of renal nerve activation on total renal blood flow, cortical blood flow, GFR or sodium excretion. The apparent ability of TAK-044 to enhance medullary blood flow responses to renal nerve stimulation may reflect an action of endogenous endothelins to blunt neurally mediated vasoconstriction in the medullary circulation. Alternatively, it may simply be secondary to the effects of endogenous endothelins on basal medullary blood flow. (c) 2006 Elsevier B.V. All rights reserved.

AB - The influence of endogenous endothelins on the neural control of renal function is poorly understood. We therefore studied the effects of endothelin blockade (combined ETA and ETB receptor antagonism using TAK-044) on the acute and prolonged effects of renal nerve stimulation in rabbits, measuring renal blood flow, glomerular filtration rate (GFR), urine flow and sodium excretion. Brief (3 min) stimulation over 0.5-8 Hz produced frequency-dependent reductions in total renal blood flow, cortical blood flow and, less markedly, medullary blood flow. TAK-044 did not significantly alter basal total renal blood flow or cortical blood flow, or their responses to nerve stimulation, but significantly increased basal medullary blood flow (P <0.01) and increased the slope of the stimulation frequency-medullary blood flow relationship (P <0.05). Prolonged (20 min) stimulation at 0, M and 2 Hz produced frequency-dependent reductions in total renal blood flow, GFR, urine flow and sodium excretion, but not medullary blood flow. Pretreatment with TAK-044 did not significantly alter these responses. Thus, endogenous endothelins do not appear to either augment or lessen the effects of renal nerve activation on total renal blood flow, cortical blood flow, GFR or sodium excretion. The apparent ability of TAK-044 to enhance medullary blood flow responses to renal nerve stimulation may reflect an action of endogenous endothelins to blunt neurally mediated vasoconstriction in the medullary circulation. Alternatively, it may simply be secondary to the effects of endogenous endothelins on basal medullary blood flow. (c) 2006 Elsevier B.V. All rights reserved.

UR - http://www.elsevier.com/locate/autneu

M3 - Article

VL - 132

SP - 8

EP - 15

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 1-2

ER -