Abstract
The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake
Original language | English |
---|---|
Pages (from-to) | 1901 - 1905 |
Number of pages | 5 |
Journal | Advanced Materials |
Volume | 26 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2014 |
Externally published | Yes |