Endocytic pH-triggered degradation of nanoengineered multilayer capsules

Kang Liang, Georgina Kate Such, Angus Johnston, Zhiyuan Zhu, Hirotaka Ejima, Joseph J Richardson, Jiwei Cui, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)


The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake
Original languageEnglish
Pages (from-to)1901 - 1905
Number of pages5
JournalAdvanced Materials
Issue number12
Publication statusPublished - 2014
Externally publishedYes

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