TY - JOUR
T1 - Endocrine Therapy for Hormone Receptor-Positive Advanced Breast Cancer
T2 - A Nation-Wide Multicenter Epidemiological Study in China
AU - Wu, Yun
AU - Han, Yiqun
AU - Yu, Pei
AU - Ouyang, Quchang
AU - Yan, Min
AU - Wang, Xiaojia
AU - Hu, Xichun
AU - Jiang, Zefei
AU - Huang, Tao
AU - Tong, Zhongsheng
AU - Wang, Shusen
AU - Yin, Yongmei
AU - Li, Hui
AU - Yang, Runxiang
AU - Yang, Huawei
AU - Teng, Yuee
AU - Sun, Tao
AU - Cai, Li
AU - Li, Hongyuan
AU - Chen, Xi
AU - He, Jianjun
AU - Liu, Xinlan
AU - Yang, Shune
AU - Qiao, Youlin
AU - Fan, Jinhu
AU - Wang, Jiayu
AU - Xu, Binghe
N1 - Publisher Copyright:
© Copyright © 2021 Wu, Han, Yu, Ouyang, Yan, Wang, Hu, Jiang, Huang, Tong, Wang, Yin, Li, Yang, Yang, Teng, Sun, Cai, Li, Chen, He, Liu, Yang, Qiao, Fan, Wang and Xu.
PY - 2021/2/11
Y1 - 2021/2/11
N2 - Background: Clinical guidelines generally recommend endocrine therapy (ET) as first-line treatment of hormone receptor-positive advanced breast cancer (HR+ ABC) whereas chemotherapy (CT) should be considered in the presence of life-threatening disease or limited clinical benefit after three sequential ET regimens. However, it is unclear if real-world clinical practice is in accordance with the current guidelines. This study was to present the real-world treatment patterns and ET regimens among HR+ ABC patients in China. Methods: Using data from the Nation-wide Multicenter Retrospective Clinical Epidemiology Study of Female Advanced Breast Cancer in China (ClinicalTrials.gov identifier: NCT03047889), we investigated the clinicopathological characteristics, clinical profiles, and treatment patterns of HR+ ABC patients from January 2012 to December 2014. Results: A total of 2,342 patients with HR+ ABC were included in this study. Our findings revealed that, in comparisons with those receiving initial CT (n = 1445), patients initiated ET (n =402) were significantly older, later recurrent after adjuvant treatment, with a lower rate of visceral involvement and a decreasing quantity of metastatic sites. A total of 1,308 patients received palliative ET while only 18.9% patients (n = 247) reached three lines of ET. Among patients completing more than one line of ET, the median treatment duration was 8 months for the first line, 6 months for the second line, and 3 months for the third line for patients receiving ET. In the advanced setting, the choices of palliative ET regimens were diverse, yet aromatase inhibitor (AI) monotherapy was still the overall mainstay of ET; in contrast, patients were less accessible to everolimus plus AI regimen in this population. Conclusions: Less than one quarter of patients initiated palliative ET for HR+ ABC in routine clinical practice. Patients who received multi-lines of ET experienced successive shorter durations following each line of therapy. This real-life data provides a solid overview of ET for HR+ ABC from China, indicating unmet need for treatment options that improve the effectiveness of endocrine therapy.
AB - Background: Clinical guidelines generally recommend endocrine therapy (ET) as first-line treatment of hormone receptor-positive advanced breast cancer (HR+ ABC) whereas chemotherapy (CT) should be considered in the presence of life-threatening disease or limited clinical benefit after three sequential ET regimens. However, it is unclear if real-world clinical practice is in accordance with the current guidelines. This study was to present the real-world treatment patterns and ET regimens among HR+ ABC patients in China. Methods: Using data from the Nation-wide Multicenter Retrospective Clinical Epidemiology Study of Female Advanced Breast Cancer in China (ClinicalTrials.gov identifier: NCT03047889), we investigated the clinicopathological characteristics, clinical profiles, and treatment patterns of HR+ ABC patients from January 2012 to December 2014. Results: A total of 2,342 patients with HR+ ABC were included in this study. Our findings revealed that, in comparisons with those receiving initial CT (n = 1445), patients initiated ET (n =402) were significantly older, later recurrent after adjuvant treatment, with a lower rate of visceral involvement and a decreasing quantity of metastatic sites. A total of 1,308 patients received palliative ET while only 18.9% patients (n = 247) reached three lines of ET. Among patients completing more than one line of ET, the median treatment duration was 8 months for the first line, 6 months for the second line, and 3 months for the third line for patients receiving ET. In the advanced setting, the choices of palliative ET regimens were diverse, yet aromatase inhibitor (AI) monotherapy was still the overall mainstay of ET; in contrast, patients were less accessible to everolimus plus AI regimen in this population. Conclusions: Less than one quarter of patients initiated palliative ET for HR+ ABC in routine clinical practice. Patients who received multi-lines of ET experienced successive shorter durations following each line of therapy. This real-life data provides a solid overview of ET for HR+ ABC from China, indicating unmet need for treatment options that improve the effectiveness of endocrine therapy.
KW - advanced breast cancer
KW - endocrine treatment
KW - epidemiological study
KW - hormone receptor-positive
KW - nationwide survey
UR - https://www.scopus.com/pages/publications/85101919146
U2 - 10.3389/fonc.2020.599604
DO - 10.3389/fonc.2020.599604
M3 - Article
C2 - 33643905
AN - SCOPUS:85101919146
SN - 2234-943X
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 599604
ER -
