TY - JOUR
T1 - Endocrine characteristics, body mass index and metabolic syndrome in women with polycystic ovary syndrome
AU - Li, Jian
AU - Wu, Qi
AU - Wang, Chi Chiu
AU - Wang, Rui
AU - Ng, Ernest H.Y.
AU - Liu, Jian Ping
AU - Mol, Ben Willem J.
AU - Wu, Xiao Ke
AU - Li, Wen Tao
AU - PCOSAct Study Group
PY - 2019/11
Y1 - 2019/11
N2 - Research question: The study aimed to evaluate the associations of endocrine and ultrasound characteristics with metabolic syndrome in women with polycystic ovary syndrome (PCOS), and whether these associations were modified by body mass index (BMI). Design: The study was a secondary analysis of baseline data from a randomized controlled trial of induction of ovulation in women with PCOS. Results: Among 947 Chinese women with PCOS, 153 (16.2%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome in women with normal (<24 kg/m2) and high (≥24 kg/m2) BMI was 3.6% and 30.5%, respectively. In all women, a high free androgen index (FAI ≥5%) was positively associated with metabolic syndrome (adjusted odds ratio [OR] 2.06, 95% confidence interval [CI] 1.11–3.82). High FAI was positively associated with metabolic syndrome among women with high BMI (adjusted OR 3.37, 95% CI 1.78–6.37), but the association was not significant in women with normal BMI (adjusted OR 1.27, 95% CI 0.34–4.70). The presence of polycystic ovary morphology was negatively associated with metabolic syndrome (adjusted OR 0.52, 95% CI 0.26–1.03) in all women (normal BMI adjusted OR 0.42, 95% CI 0.11–1.67; high BMI adjusted OR 0.54, 95% CI 0.23–1.28). LH, sex hormone-binding globulin (SHBG) and anti-Müllerian hormone (AMH) were negatively associated with metabolic syndrome. The associations of FAI, SHBG and AMH in relation to metabolic syndrome were significantly modified by BMI. Conclusion(s): The associations of endocrine characteristic with metabolic syndrome were modified by BMI in women with PCOS. Women with PCOS and normal BMI did not have an increased risk of metabolic syndrome.
AB - Research question: The study aimed to evaluate the associations of endocrine and ultrasound characteristics with metabolic syndrome in women with polycystic ovary syndrome (PCOS), and whether these associations were modified by body mass index (BMI). Design: The study was a secondary analysis of baseline data from a randomized controlled trial of induction of ovulation in women with PCOS. Results: Among 947 Chinese women with PCOS, 153 (16.2%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome in women with normal (<24 kg/m2) and high (≥24 kg/m2) BMI was 3.6% and 30.5%, respectively. In all women, a high free androgen index (FAI ≥5%) was positively associated with metabolic syndrome (adjusted odds ratio [OR] 2.06, 95% confidence interval [CI] 1.11–3.82). High FAI was positively associated with metabolic syndrome among women with high BMI (adjusted OR 3.37, 95% CI 1.78–6.37), but the association was not significant in women with normal BMI (adjusted OR 1.27, 95% CI 0.34–4.70). The presence of polycystic ovary morphology was negatively associated with metabolic syndrome (adjusted OR 0.52, 95% CI 0.26–1.03) in all women (normal BMI adjusted OR 0.42, 95% CI 0.11–1.67; high BMI adjusted OR 0.54, 95% CI 0.23–1.28). LH, sex hormone-binding globulin (SHBG) and anti-Müllerian hormone (AMH) were negatively associated with metabolic syndrome. The associations of FAI, SHBG and AMH in relation to metabolic syndrome were significantly modified by BMI. Conclusion(s): The associations of endocrine characteristic with metabolic syndrome were modified by BMI in women with PCOS. Women with PCOS and normal BMI did not have an increased risk of metabolic syndrome.
KW - Body mass index
KW - Metabolic syndrome
KW - Polycystic ovary syndrome
UR - http://www.scopus.com/inward/record.url?scp=85070881267&partnerID=8YFLogxK
U2 - 10.1016/j.rbmo.2019.06.014
DO - 10.1016/j.rbmo.2019.06.014
M3 - Article
C2 - 31444050
AN - SCOPUS:85070881267
VL - 39
SP - 868
EP - 876
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
SN - 1472-6483
IS - 5
ER -