Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

J Stone Doggett, Aaron Nilsen, Isaac Forquer, Keith W Wegmann, Lorraine Jones-Brando, Robert H Yolken, Claudia Bordon, Susan Ann Charman, Kasiram Katneni, Tracey Schultz, Jeremy Burrows, David J Hinrichs, Brigitte Meunier, Vern B Carruthers, Michael K Risco

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95 Citations (Scopus)

Abstract

Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating ocular and central nervous system disease. We show that the endochin-like quinolone (ELQ) class of compounds contains extremely potent inhibitors of T. gondii growth in vitro and is effective against acute and latent toxoplasmosis in mice.
Original languageEnglish
Pages (from-to)15936 - 15941
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number39
DOIs
Publication statusPublished - 2012

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