Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

J Stone Doggett; Aaron Nilsen; Isaac Forquer; Keith W Wegmann; Lorraine Jones-Brando; Robert H Yolken; Claudia Bordon; Susan Ann Charman; Kasiram Katneni; Tracey Schultz; Jeremy Burrows; David J Hinrichs; Brigitte Meunier; Vern B Carruthers; Michael K Risco

doi:10.1073/pnas.1208069109

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

J Stone Doggett, Aaron Nilsen, Isaac Forquer, Keith W Wegmann, Lorraine Jones-Brando, Robert H Yolken, Claudia Bordon, Susan Ann Charman, Kasiram Katneni, Tracey Schultz, Jeremy Burrows, David J Hinrichs, Brigitte Meunier, Vern B Carruthers, Michael K Risco

Centre for Drug Candidate Optimisation

Research output: Contribution to journal › Article › Research › peer-review

95 Citations (Scopus)

Abstract

Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating ocular and central nervous system disease. We show that the endochin-like quinolone (ELQ) class of compounds contains extremely potent inhibitors of T. gondii growth in vitro and is effective against acute and latent toxoplasmosis in mice.

Original language	English
Pages (from-to)	15936 - 15941
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	109
Issue number	39
DOIs	https://doi.org/10.1073/pnas.1208069109
Publication status	Published - 2012

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Cite this

Doggett, J. S., Nilsen, A., Forquer, I., Wegmann, K. W., Jones-Brando, L., Yolken, R. H., Bordon, C., Charman, S. A., Katneni, K., Schultz, T., Burrows, J., Hinrichs, D. J., Meunier, B., Carruthers, V. B., & Risco, M. K. (2012). Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15936 - 15941. https://doi.org/10.1073/pnas.1208069109

Doggett, J Stone ; Nilsen, Aaron ; Forquer, Isaac ; Wegmann, Keith W ; Jones-Brando, Lorraine ; Yolken, Robert H ; Bordon, Claudia ; Charman, Susan Ann ; Katneni, Kasiram ; Schultz, Tracey ; Burrows, Jeremy ; Hinrichs, David J ; Meunier, Brigitte ; Carruthers, Vern B ; Risco, Michael K. / Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 39. pp. 15936 - 15941.

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title = "Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis",

abstract = "Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating ocular and central nervous system disease. We show that the endochin-like quinolone (ELQ) class of compounds contains extremely potent inhibitors of T. gondii growth in vitro and is effective against acute and latent toxoplasmosis in mice.",

author = "Doggett, {J Stone} and Aaron Nilsen and Isaac Forquer and Wegmann, {Keith W} and Lorraine Jones-Brando and Yolken, {Robert H} and Claudia Bordon and Charman, {Susan Ann} and Kasiram Katneni and Tracey Schultz and Jeremy Burrows and Hinrichs, {David J} and Brigitte Meunier and Carruthers, {Vern B} and Risco, {Michael K}",

year = "2012",

doi = "10.1073/pnas.1208069109",

language = "English",

volume = "109",

pages = "15936 -- 15941",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

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}

Doggett, JS, Nilsen, A, Forquer, I, Wegmann, KW, Jones-Brando, L, Yolken, RH, Bordon, C, Charman, SA, Katneni, K, Schultz, T, Burrows, J, Hinrichs, DJ, Meunier, B, Carruthers, VB & Risco, MK 2012, 'Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 39, pp. 15936 - 15941. https://doi.org/10.1073/pnas.1208069109

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. / Doggett, J Stone; Nilsen, Aaron; Forquer, Isaac; Wegmann, Keith W; Jones-Brando, Lorraine; Yolken, Robert H; Bordon, Claudia; Charman, Susan Ann; Katneni, Kasiram; Schultz, Tracey; Burrows, Jeremy; Hinrichs, David J; Meunier, Brigitte; Carruthers, Vern B; Risco, Michael K.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 39, 2012, p. 15936 - 15941.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

AU - Doggett, J Stone

AU - Nilsen, Aaron

AU - Forquer, Isaac

AU - Wegmann, Keith W

AU - Jones-Brando, Lorraine

AU - Yolken, Robert H

AU - Bordon, Claudia

AU - Charman, Susan Ann

AU - Katneni, Kasiram

AU - Schultz, Tracey

AU - Burrows, Jeremy

AU - Hinrichs, David J

AU - Meunier, Brigitte

AU - Carruthers, Vern B

AU - Risco, Michael K

PY - 2012

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AB - Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating ocular and central nervous system disease. We show that the endochin-like quinolone (ELQ) class of compounds contains extremely potent inhibitors of T. gondii growth in vitro and is effective against acute and latent toxoplasmosis in mice.

UR - http://www.pnas.org/content/109/39/15936.full.pdf+html

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DO - 10.1073/pnas.1208069109

M3 - Article

VL - 109

SP - 15936

EP - 15941

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -