Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery

Yajun Wang; Yan Yan; Jiwei Cui; Leticia Hosta-Rigau; Joan K Heath; Edouard Nice; Frank Caruso

doi:10.1002/adma.201001497

Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery

Yajun Wang
, Yan Yan
, Jiwei Cui
, Leticia Hosta-Rigau
, Joan K Heath
, Edouard Nice
, Frank Caruso

Research output: Contribution to journal › Article › Research › peer-review

187 Citations (Scopus)

Abstract

Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.

Original language	English
Pages (from-to)	4293 - 4297
Number of pages	5
Journal	Advanced Materials
Volume	22
Issue number	38
DOIs	https://doi.org/10.1002/adma.201001497
Publication status	Published - 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1002/adma.201001497

Cite this

@article{8850e45ce3044173a34068889dc29dbd,

title = "Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery",

abstract = "Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.",

author = "Yajun Wang and Yan Yan and Jiwei Cui and Leticia Hosta-Rigau and Heath, \{Joan K\} and Edouard Nice and Frank Caruso",

year = "2010",

doi = "10.1002/adma.201001497",

language = "English",

volume = "22",

pages = "4293 -- 4297",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag GmbH \& Co. KGaA",

number = "38",

}

TY - JOUR

T1 - Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery

AU - Wang, Yajun

AU - Yan, Yan

AU - Cui, Jiwei

AU - Hosta-Rigau, Leticia

AU - Heath, Joan K

AU - Nice, Edouard

AU - Caruso, Frank

PY - 2010

Y1 - 2010

N2 - Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.

AB - Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.

UR - http://onlinelibrary.wiley.com/doi/10.1002/adma.201001497/pdf

U2 - 10.1002/adma.201001497

DO - 10.1002/adma.201001497

M3 - Article

SN - 0935-9648

VL - 22

SP - 4293

EP - 4297

JO - Advanced Materials

JF - Advanced Materials

IS - 38

ER -

Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery

Abstract

UN SDGs

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