Enantioselective Reduction of Cyclobutenones Using Ene-Reductases

Tomohiro Yasukawa; Pierre Gilles; Juliette Martin; Julien Boutet; Janine Cossy

doi:10.1002/adsc.202400417

Enantioselective Reduction of Cyclobutenones Using Ene-Reductases

Tomohiro Yasukawa, Pierre Gilles, Juliette Martin, Julien Boutet, Janine Cossy

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Enantioselective reduction of cyclobutenones to optically active cyclobutanones has been achieved by using whole-cell overexpressing Seqenzym ene-reductases (EREDs). By using these enzymes, trans-cyclobutanones were isolated in good yields and with enantiomeric excesses up to 99%.

Original language	English
Pages (from-to)	3257-3261
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	366
Issue number	15
DOIs	https://doi.org/10.1002/adsc.202400417
Publication status	Published - 6 Aug 2024
Externally published	Yes

Keywords

Asymmetric catalysis
Biocatalysis
Cyclobutanones
Cyclobutenones
Ene-Reductase
Reduction

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10.1002/adsc.202400417Licence: CC BY-NC-ND

Cite this

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abstract = "Enantioselective reduction of cyclobutenones to optically active cyclobutanones has been achieved by using whole-cell overexpressing Seqenzym ene-reductases (EREDs). By using these enzymes, trans-cyclobutanones were isolated in good yields and with enantiomeric excesses up to 99%.",

keywords = "Asymmetric catalysis, Biocatalysis, Cyclobutanones, Cyclobutenones, Ene-Reductase, Reduction",

author = "Tomohiro Yasukawa and Pierre Gilles and Juliette Martin and Julien Boutet and Janine Cossy",

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T1 - Enantioselective Reduction of Cyclobutenones Using Ene-Reductases

AU - Yasukawa, Tomohiro

AU - Gilles, Pierre

AU - Martin, Juliette

AU - Boutet, Julien

AU - Cossy, Janine

PY - 2024/8/6

Y1 - 2024/8/6

N2 - Enantioselective reduction of cyclobutenones to optically active cyclobutanones has been achieved by using whole-cell overexpressing Seqenzym ene-reductases (EREDs). By using these enzymes, trans-cyclobutanones were isolated in good yields and with enantiomeric excesses up to 99%.

AB - Enantioselective reduction of cyclobutenones to optically active cyclobutanones has been achieved by using whole-cell overexpressing Seqenzym ene-reductases (EREDs). By using these enzymes, trans-cyclobutanones were isolated in good yields and with enantiomeric excesses up to 99%.

KW - Asymmetric catalysis

KW - Biocatalysis

KW - Cyclobutanones

KW - Cyclobutenones

KW - Ene-Reductase

KW - Reduction

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DO - 10.1002/adsc.202400417

M3 - Article

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EP - 3261

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 15

ER -

Enantioselective Reduction of Cyclobutenones Using Ene-Reductases

Abstract

Keywords

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