Projects per year
Abstract
While the enantioselective Rauhut–Currier reaction is established with bis(enone) substrates, it is yet to be reported with less electrophilic bis(enoate) substrates. By exploiting high-nucleophilicity N-heterocyclic carbenes, it is possible to achieve Rauhut–Currier reactions with these substrates. The reaction is demonstrated with a range of intramolecular reactions (20 examples) and six esterification/RC reaction cascades, which all proceed with high enantioselectivity (most >93:7 er).
Original language | English |
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Pages (from-to) | 13370-13374 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 58 |
Issue number | 38 |
DOIs | |
Publication status | Published - 16 Sept 2019 |
Keywords
- bis(enoate)s
- coumarins
- enantioselective catalysis
- N-heterocyclic carbenes
- Rauhut–Currier reaction
Projects
- 1 Finished
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C=C insertion, C-H bond functionalisation, challenges to organocatalysis.
Australian Research Council (ARC), Monash University
1/01/17 → 31/12/19
Project: Research