Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA

Daniel Oves-Costales, Lijiang Song, Gregory L. Challis

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AsbA catalyses the highly enantioselective desymmetrisation of citric acid via ATP-dependent condensation with spermidine, as well as the condensation of citric acid with several spermidine analogues and the condensation of the citric acid analogue tricarballylic acid with spermidine, suggesting that it may be a useful biocatalyst for asymmetric synthesis.

Original languageEnglish
Pages (from-to)1389-1391
Number of pages3
JournalChemical Communications
Issue number11
Publication statusPublished - 2009
Externally publishedYes

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