EMT signaling: potential contribution of CRISPR/Cas gene editing

Reza Mohammadinejad, Alessio Biagioni, Ganesan Arunkumar, Rebecca Shapiro, Kun Che Chang, Mohammed Sedeeq, Aftab Taiyab, Mohammad Hashemabadi, Abbas Pardakhty, Ali Mandegary, Jean Paul Thiery, Amir Reza Aref, Iman Azimi

Research output: Contribution to journalReview ArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.

Original languageEnglish
Pages (from-to)2701-2722
Number of pages22
JournalCellular and Molecular Life Sciences
Volume77
Issue number14
DOIs
Publication statusPublished - Jul 2020
Externally publishedYes

Keywords

  • Cancer
  • CRISPR
  • Epithelial–mesenchymal transition
  • Gene editing

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