Emphysema quantified: Mapping regional airway dimensions using 2D phase contrast X-ray imaging

Marcus J. Kitchen, Genevieve A. Buckley, Lauren T. Kerr, Katie L. Lee, Kentaro Uesugi, Naoto Yagi, Stuart B. Hooper

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We have developed an analyser-based phase contrast X-ray imaging technique to measure the mean length scale of pores or particles that cannot be resolved directly by the system. By combining attenuation, phase and ultra-small angle X-ray scattering information, the technique was capable of measuring differences in airway dimension between lungs of healthy mice and those with mild and severe emphysema. Our measurements of airway dimensions from 2D images showed a 1:1 relationship to the actual airway dimensions measured using micro-CT. Using 80 images, the sensitivity and specificity were measured to be 0.80 and 0.89, respectively, with the area under the ROC curve close to ideal at 0.96. Reducing the number of images to 11 slightly decreased the sensitivity to 0.75 and the ROC curve area to 0.90, whilst the specificity remained high at 0.89.

Original languageEnglish
Pages (from-to)4176-4190
Number of pages15
JournalBiomedical Optics Express
Volume11
Issue number8
DOIs
Publication statusPublished - 1 Aug 2020

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