Emotion recognition correlates with social-neuropsychiatric dysfunction in Huntington's disease

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objectives: People with Huntington's disease (HD) experience poor social quality of life, relationship breakdown, and social withdrawal, which are mediated to some extent by socially debilitating neuropsychiatric symptoms, such as apathy and disinhibition. Social cognitive symptoms, such as impaired emotion recognition, also occur in HD, however, the extent of their association with these socially debilitating neuropsychiatric symptoms is unknown. Our study examined the relationship between emotion recognition and symptom ratings of apathy and disinhibition in HD. Methods: Thirty-two people with premanifest or symptomatic-HD completed Part 1 of The Awareness of Social Inference Test (TASIT), which is a facial emotion recognition task. In addition, we obtained severity ratings for apathy and disinhibition on the Frontal Systems Behavior Scale (FrSBe) from a close family member. Our analyses used motor symptom severity as a proxy for disease progression. Results: Emotion recognition performance was significantly associated with family-ratings of apathy, above and beyond their shared association with disease severity. We found a similar pattern for disinhibition ratings, which fell short of statistical significance. As expected, worse emotion recognition performance was correlated with higher severity in FrSBe symptom ratings. Conclusions: Our findings suggest that emotion recognition abilities relate to key socially debilitating neuropsychiatric symptoms in HD. Our results help to understand the functional significance of emotion recognition impairments in HD, and may have implications for the development of remediation programs aimed at improving patients' social quality of life.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalJournal of the International Neuropsychological Society
Volume24
Issue number5
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Apathy
  • Emotions
  • Huntington disease
  • Neurodegenerative diseases
  • Social behavior
  • Social perception

Cite this

@article{2901e046d42c4548952708b7f8c31c66,
title = "Emotion recognition correlates with social-neuropsychiatric dysfunction in Huntington's disease",
abstract = "Objectives: People with Huntington's disease (HD) experience poor social quality of life, relationship breakdown, and social withdrawal, which are mediated to some extent by socially debilitating neuropsychiatric symptoms, such as apathy and disinhibition. Social cognitive symptoms, such as impaired emotion recognition, also occur in HD, however, the extent of their association with these socially debilitating neuropsychiatric symptoms is unknown. Our study examined the relationship between emotion recognition and symptom ratings of apathy and disinhibition in HD. Methods: Thirty-two people with premanifest or symptomatic-HD completed Part 1 of The Awareness of Social Inference Test (TASIT), which is a facial emotion recognition task. In addition, we obtained severity ratings for apathy and disinhibition on the Frontal Systems Behavior Scale (FrSBe) from a close family member. Our analyses used motor symptom severity as a proxy for disease progression. Results: Emotion recognition performance was significantly associated with family-ratings of apathy, above and beyond their shared association with disease severity. We found a similar pattern for disinhibition ratings, which fell short of statistical significance. As expected, worse emotion recognition performance was correlated with higher severity in FrSBe symptom ratings. Conclusions: Our findings suggest that emotion recognition abilities relate to key socially debilitating neuropsychiatric symptoms in HD. Our results help to understand the functional significance of emotion recognition impairments in HD, and may have implications for the development of remediation programs aimed at improving patients' social quality of life.",
keywords = "Apathy, Emotions, Huntington disease, Neurodegenerative diseases, Social behavior, Social perception",
author = "Kempnich, {Clare L.} and Andrews, {Sophie C.} and Fiona Fisher and Dana Wong and Nellie Georgiou-Karistianis and Stout, {Julie C.}",
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Emotion recognition correlates with social-neuropsychiatric dysfunction in Huntington's disease. / Kempnich, Clare L.; Andrews, Sophie C.; Fisher, Fiona; Wong, Dana; Georgiou-Karistianis, Nellie; Stout, Julie C.

In: Journal of the International Neuropsychological Society, Vol. 24, No. 5, 01.05.2018, p. 417-423.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Emotion recognition correlates with social-neuropsychiatric dysfunction in Huntington's disease

AU - Kempnich, Clare L.

AU - Andrews, Sophie C.

AU - Fisher, Fiona

AU - Wong, Dana

AU - Georgiou-Karistianis, Nellie

AU - Stout, Julie C.

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AB - Objectives: People with Huntington's disease (HD) experience poor social quality of life, relationship breakdown, and social withdrawal, which are mediated to some extent by socially debilitating neuropsychiatric symptoms, such as apathy and disinhibition. Social cognitive symptoms, such as impaired emotion recognition, also occur in HD, however, the extent of their association with these socially debilitating neuropsychiatric symptoms is unknown. Our study examined the relationship between emotion recognition and symptom ratings of apathy and disinhibition in HD. Methods: Thirty-two people with premanifest or symptomatic-HD completed Part 1 of The Awareness of Social Inference Test (TASIT), which is a facial emotion recognition task. In addition, we obtained severity ratings for apathy and disinhibition on the Frontal Systems Behavior Scale (FrSBe) from a close family member. Our analyses used motor symptom severity as a proxy for disease progression. Results: Emotion recognition performance was significantly associated with family-ratings of apathy, above and beyond their shared association with disease severity. We found a similar pattern for disinhibition ratings, which fell short of statistical significance. As expected, worse emotion recognition performance was correlated with higher severity in FrSBe symptom ratings. Conclusions: Our findings suggest that emotion recognition abilities relate to key socially debilitating neuropsychiatric symptoms in HD. Our results help to understand the functional significance of emotion recognition impairments in HD, and may have implications for the development of remediation programs aimed at improving patients' social quality of life.

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