Research output per year
Research output per year
Naveen Vankadari, Jacqueline A. Wilce
Research output: Contribution to journal › Letter › Research › peer-review
The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics.
Original language | English |
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Pages (from-to) | 601-604 |
Number of pages | 4 |
Journal | Emerging Microbes & Infections |
Volume | 9 |
Issue number | 1 |
DOIs | |
Publication status | Published - 17 Mar 2020 |
Research output: Contribution to journal › Article › Research › peer-review
Research output: Contribution to journal › Article › Research › peer-review
Wilce, M., Wilce, J. & Semler, B. L.
1/01/19 → 31/12/22
Project: Research
Naveen Vankadari
9/09/20
1 item of Media coverage
Press/Media: Article/Feature
Deanna Deveson (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
David Powell (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility