Emerging strategies in the initial management of locally advanced rectal cancer

Lucy Gately, Hui Li Wong, Jeanne Tie, Rachel Wong, Margaret Lee, Belinda Lee, Azim Jalali, Peter Gibbs

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


© 2019 Future Medicine Ltd. The initial management of locally advanced rectal cancer continues to evolve and formulating the ideal treatment plan remains challenging, with a multitude of emerging treatment strategies and either limited or inconsistent data to support these. The main objective of neoadjuvant treatment is to maximize disease control and minimize toxicity and impact on quality of life. Ultimately, the optimal approach needs to be personalized to the individual. In this Review, we discuss the various strategies currently used and being further investigated in the initial treatment of patients presenting with locally advanced rectal cancer. We describe the evidence behind the current standard of care recommendations and emerging new options, as well as potential biomarkers that may assist with further refining treatment selection.
Original languageEnglish
Pages (from-to)2955-2965
Number of pages11
JournalFuture Oncology
Issue number25
Publication statusPublished - Sep 2019


  • neoadjuvant therapy
  • rectal cancer
  • sequencing

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