Emerging rules for effective antimicrobial coatings

Mario Salwiczek, Yue Qu, James Gardiner, Richard Anthony Strugnell, Trevor James Lithgow, Keith Michael McLean, Helmut Thissen

Research output: Contribution to journalArticleResearchpeer-review

173 Citations (Scopus)

Abstract

In order to colonize abiotic surfaces, bacteria and fungi undergo a profound change in their biology to form biofilms: communities of microbes embedded into a matrix of secreted macromolecules. Despite strict hygiene standards, biofilm-related infections associated with implantable devices remain a common complication in the clinic. Here, the application of highly dosed antibiotics is problematic in that the biofilm (i) provides a protective environment for microbes to evade antibiotics and/or (ii) can provide selective pressure for the evolution of antibiotic-resistant microbes. However, recent research suggests that effective prevention of biofilm formation may be achieved by multifunctional surface coatings that provide both non-adhesive and antimicrobial properties imparted by antimicrobial peptides. Such coatings are the subject of this review.
Original languageEnglish
Pages (from-to)82 - 90
Number of pages9
JournalTrends in Biotechnology
Volume32
Issue number2
DOIs
Publication statusPublished - 2014

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