TY - JOUR
T1 - Emerging nanotheranostics for 5-fluorouracil in cancer therapy
T2 - A systematic review on efficacy, safety, and diagnostic capability
AU - How, Chee Wun
AU - Teoh, Siew Li
AU - Loh, Jian Sheng
AU - Tan, Stella Li Kar
AU - Foo, Jhi Biau
AU - Ng, Hui Suan
AU - Wong, Stephenie Yoke Wei
AU - Ong, Yong Sze
N1 - Funding Information:
This work was supported by the Monash University Malaysia - School of Pharmacy Research SEED Grant Scheme [SG-3-19], ECR Research Grant [ECR-000026]; Monash Global Asia in the 21st Century (GA21) research grant [GA-ST-21-L03] and UCSI University Research Excellence and Innovation Grant (REIG-FAS-2021/005).
Publisher Copyright:
Copyright © 2022 How, Teoh, Loh, Tan, Foo, Ng, Wong and Ong.
PY - 2022/5/18
Y1 - 2022/5/18
N2 - The conventional concept of using nanocarriers to deliver chemotherapeutic drugs has advanced to accommodate additional diagnostic capability. Nanotheranostic agents (NTA), combining both treatment and diagnostic tools, are an ideal example of engineering-health integration for cancer management. Owing to the diverse materials used to construct NTAs, their safety, effectiveness, and diagnostic accuracy could vary substantially. This systematic review consolidated current NTAs incorporating 5-fluorouracil and elucidated their toxicity, anticancer efficacy, and imaging capability. Medline and Embase databases were searched up to March 18, 2022. The search, selection, and extraction were performed by the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines to ensure completeness and reproducibility. Original research papers involving 5-fluorouracil in the preparation of nanoparticles which reported their efficacy, toxicity, and diagnostic capability in animal cancer models were recruited. The quality of included studies was assessed using the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist. Nine studies were eligible for the systematic review. There was no significant toxicity reported based on animal weight and organ histology. Complete tumor remission was observed in several animal models using chemo-thermal ablation with NTAs, proving the enhancement of 5-fluorouracil efficacy. In terms of imaging performance, the time to achieve maximum tumor image intensity correlates with the presence of targeting ligand on NTAs. The NTAs, which are composed of tumor-targeting ligands, hold promises for further development. Based on the input of current NTA research on cancer, this review proposed a checklist of parameters to recommend researchers for their future NTA testing, especially in animal cancer studies.
AB - The conventional concept of using nanocarriers to deliver chemotherapeutic drugs has advanced to accommodate additional diagnostic capability. Nanotheranostic agents (NTA), combining both treatment and diagnostic tools, are an ideal example of engineering-health integration for cancer management. Owing to the diverse materials used to construct NTAs, their safety, effectiveness, and diagnostic accuracy could vary substantially. This systematic review consolidated current NTAs incorporating 5-fluorouracil and elucidated their toxicity, anticancer efficacy, and imaging capability. Medline and Embase databases were searched up to March 18, 2022. The search, selection, and extraction were performed by the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines to ensure completeness and reproducibility. Original research papers involving 5-fluorouracil in the preparation of nanoparticles which reported their efficacy, toxicity, and diagnostic capability in animal cancer models were recruited. The quality of included studies was assessed using the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist. Nine studies were eligible for the systematic review. There was no significant toxicity reported based on animal weight and organ histology. Complete tumor remission was observed in several animal models using chemo-thermal ablation with NTAs, proving the enhancement of 5-fluorouracil efficacy. In terms of imaging performance, the time to achieve maximum tumor image intensity correlates with the presence of targeting ligand on NTAs. The NTAs, which are composed of tumor-targeting ligands, hold promises for further development. Based on the input of current NTA research on cancer, this review proposed a checklist of parameters to recommend researchers for their future NTA testing, especially in animal cancer studies.
KW - cancer
KW - in vivo
KW - nanoparticle
KW - thermal ablation
KW - tumor-targeted
UR - http://www.scopus.com/inward/record.url?scp=85131505336&partnerID=8YFLogxK
U2 - 10.3389/fphar.2022.882704
DO - 10.3389/fphar.2022.882704
M3 - Review Article
C2 - 35662688
AN - SCOPUS:85131505336
SN - 1663-9812
VL - 13
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 882704
ER -
