@inbook{1dd8ede141a1465ca5f626e166f4249b,
title = "Emerging concepts in innate immunity",
abstract = "This review introduces recent concepts in innate immunity highlighting some of the latest exciting findings. These include: the discovery of the initiator of pyroptosis, Gasdermin D, and mechanisms of inflammatory caspases in innate immune signaling; the formation of oligomeric signalosomes downstream of innate immune receptors; mechanisms that shape innate immune responses, such as cellular homeostasis, cell metabolism, and pathogen viability; rapid methods of cell-to-cell communication; the interplay between the host and its microbiome and the concept of innate immunological memory. Furthermore, we discuss open questions and illustrate how technological advances, such as CRISPR/Cas9, may provide important answers for outstanding questions in the field of innate immunity.",
keywords = "ASC, Caspase, Cell death, CGAS, CRISPR/Cas9, Gasdermin D, Innate immune memory, Innate immunity, MAVS, Myddosome, PRRs, Pyroptosis",
author = "Karin Pelka and {De Nardo}, Dominic",
year = "2018",
month = jan,
day = "1",
doi = "10.1007/978-1-4939-7519-8_1",
language = "English",
isbn = "9781493975181",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
editor = "{De Nardo}, Dominic and {De Nardo}, {Christine M}",
booktitle = "Innate Immune Activation",
address = "United States of America",
}