Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Kelly L. Wyres, Jane Hawkey, Marit A.K. Hetland, Aasmund Fostervold, Ryan R. Wick, Louise M. Judd, Mohammad Hamidian, Benjamin P. Howden, Iren H. Löhr, Kathryn E. Holt

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVES: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. METHODS: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). RESULTS: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. CONCLUSIONS: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.

Original languageEnglish
Pages (from-to)577-581
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume74
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019
Externally publishedYes

Cite this

Wyres, Kelly L. ; Hawkey, Jane ; Hetland, Marit A.K. ; Fostervold, Aasmund ; Wick, Ryan R. ; Judd, Louise M. ; Hamidian, Mohammad ; Howden, Benjamin P. ; Löhr, Iren H. ; Holt, Kathryn E. / Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. In: Journal of Antimicrobial Chemotherapy. 2019 ; Vol. 74, No. 3. pp. 577-581.
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abstract = "OBJECTIVES: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. METHODS: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). RESULTS: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. CONCLUSIONS: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.",
author = "Wyres, {Kelly L.} and Jane Hawkey and Hetland, {Marit A.K.} and Aasmund Fostervold and Wick, {Ryan R.} and Judd, {Louise M.} and Mohammad Hamidian and Howden, {Benjamin P.} and L{\"o}hr, {Iren H.} and Holt, {Kathryn E.}",
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Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. / Wyres, Kelly L.; Hawkey, Jane; Hetland, Marit A.K.; Fostervold, Aasmund; Wick, Ryan R.; Judd, Louise M.; Hamidian, Mohammad; Howden, Benjamin P.; Löhr, Iren H.; Holt, Kathryn E.

In: Journal of Antimicrobial Chemotherapy, Vol. 74, No. 3, 01.03.2019, p. 577-581.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

AU - Wyres, Kelly L.

AU - Hawkey, Jane

AU - Hetland, Marit A.K.

AU - Fostervold, Aasmund

AU - Wick, Ryan R.

AU - Judd, Louise M.

AU - Hamidian, Mohammad

AU - Howden, Benjamin P.

AU - Löhr, Iren H.

AU - Holt, Kathryn E.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - OBJECTIVES: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. METHODS: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). RESULTS: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. CONCLUSIONS: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.

AB - OBJECTIVES: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. METHODS: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). RESULTS: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. CONCLUSIONS: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.

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