Abstract
The biosynthetic pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.
| Original language | English |
|---|---|
| Pages (from-to) | 3981-3983 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 3 Oct 2006 |
| Externally published | Yes |
Cite this
Stanley, A. E., Walton, L. J., Kourdi Zerikly, M., Corre, C., & Challis, G. L. (2006). Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′- bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chemical Communications, (38), 3981-3983. https://doi.org/10.1039/b609556a