Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′- bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

Anna E. Stanley, Laura J. Walton, Malek Kourdi Zerikly, Christophe Corre, Gregory L. Challis

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

The biosynthetic pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

Original languageEnglish
Pages (from-to)3981-3983
Number of pages3
JournalChemical Communications
Issue number38
DOIs
Publication statusPublished - 3 Oct 2006
Externally publishedYes

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