Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′- bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

Anna E. Stanley; Laura J. Walton; Malek Kourdi Zerikly; Christophe Corre; Gregory L. Challis

doi:10.1039/b609556a

Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′- bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

Anna E. Stanley, Laura J. Walton, Malek Kourdi Zerikly, Christophe Corre, Gregory L. Challis

Research output: Contribution to journal › Article › Research › peer-review

41 Citations (Scopus)

Abstract

The biosynthetic pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

Original language	English
Pages (from-to)	3981-3983
Number of pages	3
Journal	Chemical Communications
Issue number	38
DOIs	https://doi.org/10.1039/b609556a
Publication status	Published - 3 Oct 2006
Externally published	Yes

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abstract = "The biosynthetic pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.",

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AU - Walton, Laura J.

AU - Kourdi Zerikly, Malek

AU - Corre, Christophe

AU - Challis, Gregory L.

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AB - The biosynthetic pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

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Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′- bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

Abstract

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